Y Sashida
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Explore the profile of Y Sashida including associated specialties, affiliations and a list of published articles.
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93
Citations
462
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Recent Articles
1.
Candra E, Matsunaga K, Fujiwara H, Mimaki Y, Kuroda M, Sashida Y, et al.
J Pharm Pharmacol
. 2002 Feb;
54(2):257-62.
PMID: 11848289
We isolated eight saponins, a hexacyclic lanosterol tetraglycoside (1), a 27-norlanosterol tetraglycoside (2) and six spirostanol oligoglycosides (3-8), from the plants of the family Liliaceae. In murine leukaemic L1210 cells,...
2.
Candra E, Matsunaga K, Fujiwara H, Mimaki Y, Sashida Y, Yamakuni T, et al.
Can J Physiol Pharmacol
. 2002 Jan;
79(11):953-8.
PMID: 11760098
Two steroidal saponins, tigogenin hexasaccharide-1 (TGHS-1, (25R)-5alpha-spirostan-3beta-yl 4-O-[2-0-[3-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl]-3-0-[4-0- (alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl]-beta-D-glucopyranosyl]-3-D- galactopyranoside) and tigogenin hexasaccharide-2 (TGHS-2, (25R)-5alpha-spirostan-3beta-yl 4-O-[2-0-[3-0-(beta-D-glucopyranosyl)-beta-D-glucopyranosyl]-3-0-[4-0- (alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl]-beta-D-glucopyranosyl]beta-D-galactopyranoside), were isolated from the fresh bulbs of Camassia cusickii. In murine leukemic L1210...
3.
Mimaki Y, Yokosuka A, Kuroda M, Sashida Y
Biol Pharm Bull
. 2001 Dec;
24(11):1286-9.
PMID: 11725965
We have systematically examined the cytotoxic activities of the steroidal saponins mainly isolated from the Liliaceae plants against HL-60 human promyelocytic leukemia cells and found several structure-activity relationships. Some steroidal...
4.
Yui S, Ubukata K, Hodono K, Kitahara M, Mimaki Y, Kuroda M, et al.
Int Immunopharmacol
. 2001 Oct;
1(11):1989-2000.
PMID: 11606030
It is recognized that macrophages in peripheral tissues often proliferate under pathological conditions such as tumors, inflammation and atherosclerosis. Because the growth state of macrophages is believed to be a...
5.
Mimaki Y, Yokosuka A, Kuroda M, Hamanaka M, Sakuma C, Sashida Y
J Nat Prod
. 2001 Sep;
64(9):1226-9.
PMID: 11575962
Further phytochemical analysis aimed at the triterpene saponin constituents of the roots of Pulsatilla chinensis has resulted in the isolation of four new bisdesmosidic triterpene saponins whose aglycons are based...
6.
Mimaki Y, Kuroda M, Yokosuka A, Sashida Y
J Nat Prod
. 2001 Aug;
64(8):1069-72.
PMID: 11520229
Two new cholestane bisdesmosides (1, 2) based upon (22S)-cholest-5-ene-3 beta,16 beta,22-triol with an acetyl group at the sugar moiety and three new ones (3-5) based upon (22S)-cholest-5-ene-1 beta,3 beta,16 beta,22-tetrol,...
7.
Kuroda M, Mimaki Y, Yokosuka A, Sashida Y
Chem Pharm Bull (Tokyo)
. 2001 Aug;
49(8):1042-6.
PMID: 11515577
Further search for cytotoxic compounds contained in the bulbs of Galtonia candicans (Liliaceae) led to the isolation of four potent cytotoxic cholestane glycosides (1-4) based upon 3beta,16beta,17alpha-trihydroxycholest-5-en-22-one, three of which...
8.
Pengsuparp T, Indra B, Nakagawasai O, Tadano T, Mimaki Y, Sashida Y, et al.
Eur J Pharmacol
. 2001 Aug;
425(3):211-8.
PMID: 11513840
The pharmacological properties of geissoschizine methyl ether, isolated from Uncaria sinensis Oliv., were analyzed in vitro and in vivo using mice central serotonin neurons. In the in vitro experiment, geissoschizine...
9.
Kuroda M, Mimaki Y, Hasegawa F, Yokosuka A, Sashida Y, Sakagami H
Chem Pharm Bull (Tokyo)
. 2001 Jun;
49(6):726-31.
PMID: 11411525
Phytochemical analysis of the bulbs of Camassia leichtlinii (Liliaceae) resulted in the isolation of six new spirostanol saponins, a new furostanol saponin, a cholestane glucoside, and four known steroidal saponins....
10.
Mimaki Y, Fukushima M, Yokosuka A, Sashida Y, Furuya S, Sakagami H
Phytochemistry
. 2001 Jun;
57(5):773-9.
PMID: 11397447
Five triterpene glycosides were isolated from the MeOH extract of Sanguisorba officinalis (Rosaceae) roots, as confirmed by detailed analysis of their 1H, 13C, and two-dimensional NMR data, and by the...