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Y Iwayama

Explore the profile of Y Iwayama including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 73
Citations 586
Followers 0
Related Specialties
Dentistry
Psychiatry
Pharmacology
Top 10 Co-Authors
T Shibutani
T Yoshikawa
M Shiraki
T Miki
Y Katsutani
Y Nomura
Y Murahashi
I TAKAYANAGI
Y Doi
Y Moriwaki
Published In
Nihon Shishubyo Gakkai Kaishi
Gifu Shika Gakkai Zasshi
Transl Psychiatry
J Periodontal Res
J Biomed Mater Res
Affiliations
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Recent Articles
1.
A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility
Kimura H, Fujita Y, Kawabata T, Ishizuka K, Wang C, Iwayama Y, et al.
Transl Psychiatry . 2017 Sep; 7(8):e1214. PMID: 28892071
Reticulon 4 receptor (RTN4R) plays an essential role in regulating axonal regeneration and plasticity in the central nervous system through the activation of rho kinase, and is located within chromosome...
2.
Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes
Maekawa M, Watanabe A, Iwayama Y, Kimura T, Hamazaki K, Balan S, et al.
Transl Psychiatry . 2017 Sep; 7(9):e1229. PMID: 28872641
The risk of schizophrenia is increased in offspring whose mothers experience malnutrition during pregnancy. Polyunsaturated fatty acids (PUFAs) are dietary components that are crucial for the structural and functional integrity...
3.
Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders
Ishizuka K, Fujita Y, Kawabata T, Kimura H, Iwayama Y, Inada T, et al.
Transl Psychiatry . 2017 Aug; 7(8):e1184. PMID: 28763059
CX3CR1, a G protein-coupled receptor solely expressed by microglia in the brain, has been repeatedly reported to be associated with neurodevelopmental disorders including schizophrenia (SCZ) and autism spectrum disorders (ASD)...
4.
Analysis of induced pluripotent stem cells carrying 22q11.2 deletion
Toyoshima M, Akamatsu W, Okada Y, Ohnishi T, Balan S, Hisano Y, et al.
Transl Psychiatry . 2016 Nov; 6(11):e934. PMID: 27801899
Given the complexity and heterogeneity of the genomic architecture underlying schizophrenia, molecular analyses of these patients with defined and large effect-size genomic defects could provide valuable clues. We established human-induced...
5.
Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis
Yoshimi N, Futamura T, Bergen S, Iwayama Y, Ishima T, Sellgren C, et al.
Mol Psychiatry . 2016 Jan; 21(11):1504-1510. PMID: 26782057
Although evidence for mitochondrial dysfunction in the pathogenesis of bipolar disorder (BD) has been reported, the precise biological basis remains unknown, hampering the search for novel biomarkers. In this study,...
6.
Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia
Uezato A, Yamamoto N, Iwayama Y, Hiraoka S, Hiraaki E, Umino A, et al.
Transl Psychiatry . 2015 Oct; 5:e654. PMID: 26440542
The human discs, large homolog 1 gene (DLG1) is mapped to the schizophrenia-susceptibility locus 3q29, and it encodes a scaffold protein that interacts with the N-methyl-D-aspartate receptor presumably dysregulated in...
7.
22q11.2 deletion carriers and schizophrenia-associated novel variants
Balan S, Iwayama Y, Toyota T, Toyoshima M, Maekawa M, Yoshikawa T
Br J Psychiatry . 2014 Feb; 204:398-9. PMID: 24482440
The penetrance of schizophrenia risk in carriers of the 22q11.2 deletion is high but incomplete, suggesting the possibility of additional genetic defects. We performed whole exome sequencing on two individuals...
8.
Schizophrenia with the 22q11.2 deletion and additional genetic defects: case history
Toyosima M, Maekawa M, Toyota T, Iwayama Y, Arai M, Ichikawa T, et al.
Br J Psychiatry . 2011 Sep; 199(3):245-6. PMID: 21881099
The 22q11.2 deletion is the most prominent known genetic risk factor for schizophrenia, but its penetrance is at most approximately 50% suggesting that additional risk factors are required for disease...
9.
Functional (GT)n polymorphisms in promoter region of N-methyl-d-aspartate receptor 2A subunit (GRIN2A) gene affect hippocampal and amygdala volumes
Inoue H, Yamasue H, Tochigi M, Suga M, Iwayama Y, Abe O, et al.
Genes Brain Behav . 2010 Jan; 9(3):269-75. PMID: 20070378
The glutamate system including N-methyl-d-aspartate (NMDA) affects synaptic formation, plasticity and maintenance. Recent studies have shown a variable (GT)n polymorphism in the promoter region of the NMDA subunit gene (GRIN2A)...
10.
SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects
Lepagnol-Bestel A, Maussion G, Boda B, Cardona A, Iwayama Y, Delezoide A, et al.
Mol Psychiatry . 2008 Jan; 13(4):385-97. PMID: 18180767
Autism is a neurodevelopmental disorder with a strong genetic component, probably involving several genes. Genome screens have provided evidence of linkage to chromosome 2q31-q33, which includes the SLC25A12 gene. Association...