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Y Hinokio

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Articles 25
Citations 967
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Recent Articles
11.
Hinokio Y, Suzuki S, Hirai M, Chiba M, Hirai A, Toyota T
Diabetologia . 1999 Sep; 42(8):995-8. PMID: 10491760
Aims/hypothesis: Augmented oxidative stress induced by hyperglycaemia possibly contributes to the pathogenesis of diabetic complications. Oxidative stress is known to increase the conversion of deoxyguanosine to 8-oxo, 2'-deoxyguanosine in DNA....
12.
Hirai M, Suzuki S, Hinokio Y, Chiba M, Kasuga S, Hirai A, et al.
Diabetologia . 1998 Jul; 41(6):742-3. PMID: 9662062
No abstract available.
13.
Suzuki S, Hinokio Y, OHTOMO M, Hirai M, Hirai A, Chiba M, et al.
Diabetologia . 1998 Jun; 41(5):584-8. PMID: 9628277
The characteristic clinical features of diabetes mellitus with mitochondrial DNA (mtDNA) 3243(A-G) mutation are progressive insulin secretory defect, neurosensory deafness and maternal inheritance, referred to as maternally inherited diabetes mellitus...
14.
Hirai M, Suzuki S, Onoda M, Hinokio Y, Hirai A, OHTOMO M, et al.
J Clin Endocrinol Metab . 1998 Mar; 83(3):992-4. PMID: 9506761
Accumulating reports indicate a relationship between mitochondrial DNA mutation and impaired glucose-induced insulin secretion leading to a subtype of noninsulin-dependent diabetes mellitus. DNA from a 45-yr-old Japanese woman with noninsulin-dependent...
15.
Horikawa Y, Iwasaki N, Hara M, Furuta H, Hinokio Y, Cockburn B, et al.
Nat Genet . 1997 Dec; 17(4):384-5. PMID: 9398836
No abstract available.
16.
Furuta H, Iwasaki N, Oda N, Hinokio Y, Horikawa Y, Yamagata K, et al.
Diabetes . 1997 Oct; 46(10):1652-7. PMID: 9313765
Hepatocyte nuclear factor-4 alpha (HNF-4 alpha) is a member of the nuclear receptor superfamily, a class of ligand-activated transcription factors. A nonsense mutation in the gene encoding this transcription factor...
17.
Iwasaki N, Oda N, Ogata M, Hara M, Hinokio Y, Oda Y, et al.
Diabetes . 1997 Sep; 46(9):1504-8. PMID: 9287053
Recent studies have shown that mutations in the hepatocyte nuclear factor (HNF)-1alpha gene are the cause of maturity-onset diabetes of the young type 3 (MODY3). We have screened 193 unrelated...
18.
Suzuki Y, Suzuki S, Hinokio Y, Chiba M, Atsumi Y, Hosokawa K, et al.
Diabetes Care . 1997 Jul; 20(7):1138-40. PMID: 9203451
Objective: To present a novel mitochondrial DNA mutation in a diabetic family Research Design And Methods: The proband was a 64-year-old man. In the family, diabetes was maternally inherited. He...
19.
Suzuki S, OHTOMO M, Satoh Y, Kawasaki H, Hirai M, Hirai A, et al.
Diabetes Res Clin Pract . 1996 Jun; 33(1):43-51. PMID: 8877275
The open trial was designed to evaluate the effects of long-term antihypertensive treatment with the calcium-channel blocker, manidipine and the angiotensin converting enzyme (ACE) inhibitor, delapril on insulin sensitivity in...
20.
Hirai M, Suzuki S, Onoda M, Hinokio Y, Ai L, Hirai A, et al.
Biochem Biophys Res Commun . 1996 Feb; 219(3):951-5. PMID: 8645285
Mitochondrial DNA (mtDNA) mutation is associated with a subtype of non-insulin-dependent diabetes mellitus (NIDDM). We identified two homoplasmic mtDNA mutations at the positions of 3394 (T-C) and 3423 (G-T) in...