Y A Blednov
Overview
Explore the profile of Y A Blednov including associated specialties, affiliations and a list of published articles.
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26
Citations
846
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Recent Articles
1.
Varodayan F, Pahng A, Davis T, Gandhi P, Bajo M, Steinman M, et al.
Brain Behav Immun
. 2023 Mar;
110:125-139.
PMID: 36863493
Neuroimmune pathways regulate brain function to influence complex behavior and play a role in several neuropsychiatric diseases, including alcohol use disorder (AUD). In particular, the interleukin-1 (IL-1) system has emerged...
2.
Erickson E, DaCosta A, Mason S, Blednov Y, Mayfield R, Harris R
Neuropsychopharmacology
. 2020 May;
46(3):500-508.
PMID: 32464636
Astrocytes are fundamental building blocks of the central nervous system. Their dysfunction has been implicated in many psychiatric disorders, including alcohol use disorder, yet our understanding of their functional role...
3.
Mayfield J, Arends M, Harris R, Blednov Y
Int Rev Neurobiol
. 2016 Apr;
126:293-355.
PMID: 27055617
In this chapter, we review the effects of global null mutant and overexpressing transgenic mouse lines on voluntary self-administration of alcohol. We examine approximately 200 publications pertaining to the effects...
4.
Marballi K, Genabai N, Blednov Y, Harris R, Ponomarev I
Genes Brain Behav
. 2015 Oct;
15(3):318-26.
PMID: 26482798
Alcoholism is associated with dysregulation in the neural circuitry that mediates motivated and goal-directed behaviors. The dopaminergic (DA) connection between the ventral tegmental area (VTA) and the nucleus accumbens is...
5.
Bajo M, Herman M, Varodayan F, Oleata C, Madamba S, Harris R, et al.
Brain Behav Immun
. 2014 Dec;
45:189-97.
PMID: 25479427
The IL-1 receptor antagonist (IL-1ra), encoded by the Il1rn gene, is an endogenous antagonist of the IL-1 receptor. Studies of Il1rn knockout (KO) and wild type (WT) mice identified differences...
6.
Blednov Y, Benavidez J, Black M, Chandra D, Homanics G, Rudolph U, et al.
Neuropharmacology
. 2012 Nov;
67:46-56.
PMID: 23147414
GABA type A receptors (GABA(A)-R) are important for ethanol actions and it is of interest to link individual subunits with specific ethanol behaviors. We studied null mutant mice for six...
7.
Blednov Y, Mayfield R, Belknap J, Harris R
Genes Brain Behav
. 2012 Mar;
11(4):424-35.
PMID: 22405477
Behavioral studies on genetically diverse mice have proven powerful for determining relationships between phenotypes and have been widely used in alcohol research. Most of these studies rely on naturally occurring...
8.
Blednov Y, Benavidez J, Geil C, Perra S, Morikawa H, Harris R
Brain Behav Immun
. 2011 Jan;
25 Suppl 1:S92-S105.
PMID: 21266194
Previous studies showed that mice with genetic predisposition for high alcohol consumption as well as human alcoholics show changes in brain expression of genes related to immune signaling. In addition,...
9.
Harris R, Osterndorff-Kahanek E, Ponomarev I, Homanics G, Blednov Y
Neurosci Lett
. 2010 Nov;
488(1):31-5.
PMID: 21056629
Knock-in mice were constructed with mutations in the α1 (H(270), A(277)) and α2 (H(270), A(277)) subunits of the GABAA receptor, which resulted in receptors that lacked modulation by ethanol but...
10.
Blednov Y, Borghese C, McCracken M, Benavidez J, Geil C, Osterndorff-Kahanek E, et al.
J Pharmacol Exp Ther
. 2010 Sep;
336(1):145-54.
PMID: 20876231
GABA type A receptors (GABA(A)-Rs) are potential targets of ethanol. However, there are multiple subtypes of this receptor, and, thus far, individual subunits have not been definitively linked with specific...