Xukun Lu
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Explore the profile of Xukun Lu including associated specialties, affiliations and a list of published articles.
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26
Citations
535
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Recent Articles
11.
Huo D, Yu Z, Li R, Gong M, Sidoli S, Lu X, et al.
Mol Cell
. 2022 Feb;
82(6):1169-1185.e7.
PMID: 35202573
Polycomb group (PcG) proteins are essential for post-implantation development by depositing repressive histone modifications at promoters, mainly CpG islands (CGIs), of developmental regulator genes. However, promoter PcG marks are erased...
12.
Zhang J, Liu W, Li G, Xu C, Nie X, Qin D, et al.
FASEB J
. 2021 Dec;
36(2):e22128.
PMID: 34972250
Alternative splicing (AS) is an important mechanism to regulate organogenesis and fertility. Breast carcinoma amplified sequence 2 (BCAS2) is one of the core components of the PRP19 complex, a multiple...
13.
Lu X, Zhang Y, Wang L, Wang L, Wang H, Xu Q, et al.
Sci Adv
. 2021 Nov;
7(48):eabi6178.
PMID: 34818044
While mouse remains the most popular model, the conservation of parental-to-embryonic epigenetic transition across mammals is poorly defined. Through analysis of oocytes and early embryos in human, bovine, porcine, rat,...
14.
Wang X, Xiang Y, Yu Y, Wang R, Zhang Y, Xu Q, et al.
Cell Res
. 2021 Feb;
31(5):526-541.
PMID: 33608671
The pluripotency of mammalian early and late epiblast could be recapitulated by naïve embryonic stem cells (ESCs) and primed epiblast stem cells (EpiSCs), respectively. However, these two states of pluripotency...
15.
Meng T, Lu X, Guo L, Hou G, Ma X, Li Q, et al.
FASEB J
. 2018 Aug;
33(1):1179-1187.
PMID: 30110177
N6-methyladenosine (mA) is the most prevalent and reversible internal modification of mammalian messenger and noncoding RNAs mediated by specific mA writer, reader, and eraser proteins. As an mA writer, the...
16.
Lu X, Zhao Z, Wang X, Zhang X, Zhai Y, Deng W, et al.
Biol Open
. 2018 Mar;
7(3).
PMID: 29592913
Alternative splicing (AS) and alternative promoter (AP) usage expand the repertories of mammalian transcriptome profiles and thus diversify gene functions. However, our knowledge about the extent and functions of AS...
17.
Yu Y, Wang X, Zhang X, Zhai Y, Lu X, Ma H, et al.
Stem Cell Res Ther
. 2018 Jan;
9(1):2.
PMID: 29304842
Background: Pluripotent stem cells hold great promise for regenerative medicine. However, before clinical application, reproducible protocols for pluripotent stem cell differentiation should be established. Extracellular signal-regulated protein kinase (ERK) signaling...
18.
Lu X, Gao Z, Qin D, Li L
Trends Mol Med
. 2017 Oct;
23(11):1014-1023.
PMID: 28993030
Prior to zygotic genome activation, early mammalian development relies on maternal-effect genes to orchestrate the oocyte-to-embryo transition. Recently, a subcortical maternal complex (SCMC) was identified to be essential for mouse...
19.
Gao Z, Zhang X, Yu X, Qin D, Xiao Y, Yu Y, et al.
J Mol Cell Biol
. 2017 Oct;
10(1):74-88.
PMID: 28992324
We previously identified a subcortical maternal complex (SCMC) that is essential for early embryogenesis and female fertility in mice. However, the molecular mechanism by which the SCMC affects female fertility...
20.
Liu W, Wang F, Xu Q, Shi J, Zhang X, Lu X, et al.
Nat Commun
. 2017 Jan;
8:14182.
PMID: 28128212
Breast cancer amplified sequence 2 (BCAS2) is involved in multiple biological processes, including pre-mRNA splicing. However, the physiological roles of BCAS2 are still largely unclear. Here we report that BCAS2...