Xukun Lu
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Explore the profile of Xukun Lu including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
535
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Recent Articles
1.
Du Z, Hu L, Zou Z, Liu M, Li Z, Lu X, et al.
Nat Genet
. 2024 Sep;
56(10):2185-2198.
PMID: 39256583
X chromosome inactivation triggers a dramatic reprogramming of transcription and chromosome architecture. However, how the chromatin organization of inactive X chromosome is established de novo in vivo remains elusive. Here,...
2.
Li L, Lai F, Liu L, Lu X, Hu X, Liu B, et al.
Nat Struct Mol Biol
. 2024 Jan;
31(6):950-963.
PMID: 38243114
During the first lineage segregation, a mammalian totipotent embryo differentiates into the inner cell mass (ICM) and trophectoderm (TE). However, how transcription factors (TFs) regulate this earliest cell-fate decision in...
3.
Li L, Lai F, Hu X, Liu B, Lu X, Lin Z, et al.
Science
. 2023 Dec;
382(6676):eadi5516.
PMID: 38096290
Pioneer transcription factors (TFs), such as OCT4 and SOX2, play crucial roles in pluripotency regulation. However, the master TF-governed pluripotency regulatory circuitry was largely inferred from cultured cells. In this...
4.
Lai F, Li L, Hu X, Liu B, Zhu Z, Liu L, et al.
Cell Res
. 2023 Nov;
33(12):952-966.
PMID: 37935903
Zygotic genome activation (ZGA) marks the beginning of the embryonic program for a totipotent embryo, which gives rise to the inner cell mass (ICM) where pluripotent epiblast arises, and extraembryonic...
5.
Nie X, Xu Q, Xu C, Chen F, Wang Q, Qin D, et al.
Nat Commun
. 2023 Jul;
14(1):4275.
PMID: 37460529
Zygotic genome activation (ZGA) is essential for early embryonic development. However, the regulation of ZGA remains elusive in mammals. Here we report that a maternal factor TDP-43, a nuclear transactive...
6.
Zhu F, Yan N, Lu X, Xu J, Gu H, Liang J, et al.
Adv Mater
. 2023 Mar;
36(22):e2211609.
PMID: 36989141
Induced pluripotent stem cells (iPSCs) have wide applications in disease modeling, personalized medicine, and tissue engineering. The generation of iPSCs from somatic cells via transcriptional-factor- or chemical molecule-based approaches are...
7.
Liu W, Lu X, Zhao Z, Su R, Li Q, Xue Y, et al.
Elife
. 2022 Nov;
11.
PMID: 36355419
Alternative splicing expands the transcriptome and proteome complexity and plays essential roles in tissue development and human diseases. However, how alternative splicing regulates spermatogenesis remains largely unknown. Here, using a...
8.
Meng T, Lei W, Lu X, Liu X, Ma X, Nie X, et al.
Int J Biol Sci
. 2022 Jul;
18(11):4513-4531.
PMID: 35864958
During oocyte growth, various epigenetic modifications are gradually established, accompanied by accumulation of large amounts of mRNAs and proteins. However, little is known about the relationship between epigenetic modifications and...
9.
Wang X, Xiang Y, Yu Y, Wang R, Zhang Y, Xu Q, et al.
Cell Res
. 2022 Jul;
32(9):866.
PMID: 35821093
No abstract available.
10.
Quan Y, Wang M, Xu C, Wang X, Wu Y, Qin D, et al.
Nucleic Acids Res
. 2022 Apr;
50(8):4414-4435.
PMID: 35390160
Mammalian early epiblasts at different phases are characterized by naïve, formative, and primed pluripotency states, involving extensive transcriptome changes. Here, we report that deadenylase Cnot8 of Ccr4-Not complex plays essential...