Xuekui Yu
Overview
Explore the profile of Xuekui Yu including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
1366
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Recent Articles
1.
Miao Y, Fan F, Cheng Y, Jia L, Song S, Huan X, et al.
Nat Commun
. 2025 Mar;
16(1):2526.
PMID: 40087304
Anticipating and addressing resistance is essential for maximizing the potential of an oncology target and effectively addressing clinical needs. In this study, we aimed to proactively outline the resistance mechanisms...
2.
Wang X, Zhan Z, Wang Z, Zhang Y, Zhao K, Li H, et al.
MedComm (2020)
. 2024 Dec;
6(1):e70001.
PMID: 39712456
Agonists of the stimulator of interferon genes (STING) pathway are increasingly being recognized as a promising new approach in the treatment of cancer. Although progress in clinical trials for STING...
3.
Liu Y, Zhou Z, Guan F, Han Z, Zhu C, Ye S, et al.
J Mol Biol
. 2024 Sep;
436(22):168795.
PMID: 39299383
Endogenous ligands for alicarboxylic acid receptors are important metabolic intermediates that play a significant role in regulating body energy and maintaining homeostasis. However, the molecular mechanism of alicarboxylate ligand-mediated counterpart...
4.
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, et al.
Nat Commun
. 2024 Apr;
15(1):3531.
PMID: 38670961
E6AP dysfunction is associated with Angelman syndrome and Autism spectrum disorder. Additionally, the host E6AP is hijacked by the high-risk HPV E6 to aberrantly ubiquitinate the tumor suppressor p53, which...
5.
Li Z, Pang J, Gao R, Wang Q, Zhang M, Yu X
Nat Commun
. 2023 Apr;
14(1):2025.
PMID: 37041152
The portal-scaffold complex is believed to nucleate the assembly of herpesvirus procapsids. During capsid maturation, two events occur: scaffold expulsion and DNA incorporation. The portal-scaffold interaction and the conformational changes...
6.
Xie Z, Wang Z, Fan F, Zhou J, Hu Z, Wang Q, et al.
Cell Discov
. 2022 Dec;
8(1):133.
PMID: 36513640
Stimulator of interferon gene (STING) is increasingly exploited for the potential in cancer immunotherapy, yet its mechanism of activation remains not fully understood. Herein, we designed a novel STING agonist,...
7.
Huang S, Xu P, Shen D, Simon I, Mao C, Tan Y, et al.
Mol Cell
. 2022 Jun;
82(14):2681-2695.e6.
PMID: 35714614
Serotonin (or 5-hydroxytryptamine, 5-HT) is an important neurotransmitter that activates 12 different G protein-coupled receptors (GPCRs) through selective coupling of G, G or G proteins. The structural basis for G...
8.
Li Z, Pang J, Dong L, Yu X
Nat Commun
. 2021 Jul;
12(1):4538.
PMID: 34315863
How the human cytomegalovirus (HCMV) genome-the largest among human herpesviruses-is packaged, retained, and ejected remains unclear. We present the in situ structures of the symmetry-mismatched portal and the capsid vertex-specific...
9.
Yin W, Luan X, Li Z, Zhou Z, Wang Q, Gao M, et al.
Nat Struct Mol Biol
. 2021 Mar;
28(3):319-325.
PMID: 33674802
The COVID-19 pandemic caused by nonstop infections of SARS-CoV-2 has continued to ravage many countries worldwide. Here we report that suramin, a 100-year-old drug, is a potent inhibitor of the...
10.
Xu P, Huang S, Mao C, Krumm B, Zhou X, Tan Y, et al.
Mol Cell
. 2021 Feb;
81(6):1147-1159.e4.
PMID: 33548201
The dopamine system, including five dopamine receptors (D1R-D5R), plays essential roles in the central nervous system (CNS), and ligands that activate dopamine receptors have been used to treat many neuropsychiatric...