Xizhu Fang
Overview
Explore the profile of Xizhu Fang including associated specialties, affiliations and a list of published articles.
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10
Citations
39
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Recent Articles
1.
Wang Q, Sun X, Fang X, Wang Z, Wang H, Sun S, et al.
Acta Biomater
. 2024 Jun;
183:306-317.
PMID: 38838902
Advanced hepatocellular carcinoma (HCC) is one of the most challenging cancers because of its heterogeneous and aggressive nature, precluding the use of curative treatments. Sorafenib (SOR) is the first approved...
2.
Guillen-Quispe Y, Kim S, Saeidi S, Zhou T, Zheng J, Kim S, et al.
Free Radic Biol Med
. 2023 Jul;
207:296-307.
PMID: 37473874
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) isomerizes the nearby proline (Pro) residue when it detects phosphorylated serine (Ser) or threonine (Thr) of target proteins, altering their structure, stability, function, and...
3.
Kim S, Lee S, Kim S, Fang X, Hur J, Sozen E, et al.
Redox Biol
. 2023 Mar;
62:102666.
PMID: 36934646
Docosahexaenoic acid (DHA), a representative omega-3 (ω-3) polyunsaturated fatty acids, undergoes metabolism to produce biologically active electrophilic species. 17-Oxo-DHA is one such reactive metabolite generated from DHA by cyclooxygenase-2 and...
4.
Zheng J, Kim S, Saeidi S, Kim S, Fang X, Lee Y, et al.
Free Radic Biol Med
. 2022 Dec;
194:347-356.
PMID: 36460215
Hypoxia-inducible factor-1α (HIF-1α) is highly expressed/activated in most hypoxic tumors including hepatocellular carcinoma (HCC). Another key transcription factor, nuclear factor erythroid 2-related factor 2 (NRF2), is also constitutively overactivated in...
5.
Fang X, Lee Y, Jang J, Kim S, Kim S, Kim D, et al.
Life Sci
. 2022 Nov;
313:121217.
PMID: 36442525
Aims: Aberrant overactivation/overexpression of NRF2 is implicated as a driving event in tumor progression, which has been attributed to its mutation or inactivation of the inhibitory protein, KEAP1. However, alternative...
6.
Zheng J, Kim D, Fang X, Kim S, Saeidi S, Kim S, et al.
Int J Mol Sci
. 2022 May;
23(10).
PMID: 35628208
Nuclear factor erythroid 2-related factor 2 (NRF2) is a key transcription factor involved in protection against initiation of carcinogenesis in normal cells. Notably, recent studies have demonstrated that aberrant activation...
7.
Jagadeesh A, Fang X, Kim S, Guillen-Quispe Y, Zheng J, Surh Y, et al.
J Cancer Prev
. 2022 Apr;
27(1):7-15.
PMID: 35419301
Heme oxygenase-1 (HO-1) is a critical stress-responsive enzyme that has antioxidant and anti-inflammatory functions. HO-1 catalyzes heme degradation, which gives rise to the formation of carbon monoxide (CO), biliverdin, and...
8.
Lee Y, Kim S, Fang X, Song N, Kim D, Suh J, et al.
Mol Oncol
. 2021 Nov;
16(7):1555-1571.
PMID: 34826187
Sirtuin 1 (SIRT1), an NAD -dependent histone/protein deacetylase, has multifaceted functions in various biological events such as inflammation, aging, and energy metabolism. The role of SIRT1 in carcinogenesis, however, is...
9.
Kim S, Cho N, Hahn Y, Kim S, Fang X, Surh Y
J Cancer Prev
. 2021 Oct;
26(3):207-217.
PMID: 34703823
STAT3 plays a prominent role in proliferation and survival of tumor cells. Thus, STAT3 has been considered to be a prime target for development of anti-cancer therapeutics. The electrophilic cyclopentenone...
10.
Jung J, Lee Y, Fang X, Kim S, Kim S, Kim D, et al.
Arch Biochem Biophys
. 2021 Mar;
703:108847.
PMID: 33766523
SIRT1 is a mammalian NAD-dependent deacetylase, which is known to be involved in various physiological events, such as adaptive response to environmental stresses including caloric restriction, as well as in...