Xirong Zheng
Overview
Explore the profile of Xirong Zheng including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
305
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Recent Articles
1.
Waldschmidt J, Sotudeh N, Arora S, Vijaykumar T, Anand P, Stuart H, et al.
Blood Adv
. 2025 Jan;
9(5):1132-1136.
PMID: 39813623
No abstract available.
2.
Nagaraja Shastri P, Shah N, Lechmann M, Mody H, Retter M, Zhu M, et al.
Clin Pharmacol Ther
. 2024 Sep;
117(1):34-55.
PMID: 39295563
T-cell-engaging bispecific antibodies (TCEs) that target tumor antigens and T cells have shown great promise in treating cancer, particularly in hematological indications. The clinical development of TCEs often involves a...
3.
Masilamani M, Jawa V, Dai Y, Das R, Park A, Lamba M, et al.
Clin Pharmacol Ther
. 2023 Jul;
114(3):664-672.
PMID: 37422675
Recently, multiple chimeric antigen receptor T-cell (CAR-T)-based therapies have been approved for treating hematological malignancies, targeting CD19 and B-cell maturation antigen. Unlike protein or antibody therapies, CAR-T therapies are "living...
4.
Shang L, Zheng X, Zhang T, Deng J, Zhan C, Zheng F
Toxicol Rep
. 2022 Dec;
9:1586-1594.
PMID: 36518391
As most cocaine users drink alcohol, it is interesting to understand how a non-lethal dose of alcohol affects the metabolism and toxicity of cocaine. In this study, we examined the...
5.
Deng J, Zheng X, Shang L, Zhan C, Zheng F
Addict Biol
. 2022 Oct;
27(6):e13236.
PMID: 36301205
As well known, cocaine induces stimulant effects and dopamine transporter (DAT) trafficking to the plasma membrane of dopaminergic neurons. In the present study, we examined cocaine-induced hyperactivity along with cocaine-induced...
6.
Zheng F, Jin Z, Deng J, Chen X, Zheng X, Wang G, et al.
Bioconjug Chem
. 2022 Jun;
33(7):1340-1349.
PMID: 35767675
It is particularly challenging to develop a truly effective pharmacotherapy for cocaine use disorder (CUD) treatment. Accelerating cocaine metabolism hydrolysis at cocaine benzoyl ester using an efficient cocaine hydrolase (CocH)...
7.
Recovery of dopaminergic system after cocaine exposure and impact of a long-acting cocaine hydrolase
Deng J, Zhang T, Zheng X, Shang L, Zhan C, Zheng F
Addict Biol
. 2022 Jun;
27(4):e13179.
PMID: 35754103
Dysregulation of dopamine transporters (DAT) within the dopaminergic system is an important biomarker of cocaine exposure. Depending on cocaine amount in-taken, one-time exposure in rats could lead to most (>95%...
8.
Deng J, Kim K, Zheng X, Shang L, Zhan C, Zheng F
Addict Biol
. 2021 Aug;
27(1):e13089.
PMID: 34363291
Cocaine blocks dopamine uptake via dopamine transporter (DAT) on plasma membrane of neuron cells and, as a result, produces the high and induces DAT trafficking to plasma membrane which contributes...
9.
Singh A, Chen W, Zheng X, Mody H, Carpenter T, Zong A, et al.
CPT Pharmacometrics Syst Pharmacol
. 2021 Feb;
10(4):362-376.
PMID: 33565700
Despite tremendous success of chimeric antigen receptor (CAR) T cell therapy in clinical oncology, the dose-exposure-response relationship of CAR-T cells in patients is poorly understood. Moreover, the key drug-specific and...
10.
Liu C, Ayyar V, Zheng X, Chen W, Zheng S, Mody H, et al.
Clin Pharmacol Ther
. 2020 Oct;
109(3):716-727.
PMID: 33002189
Chimeric antigen receptor (CAR)-T cell therapy has achieved considerable success in treating B-cell hematologic malignancies. However, the challenges of extending CAR-T therapy to other tumor types, particularly solid tumors, remain...