Xin-An Chen
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Explore the profile of Xin-An Chen including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Chuang C, Chen C, Chen X, Lee C, Chang Y, Tsai M, et al.
Int J Biol Macromol
. 2025 Feb;
304(Pt 1):140689.
PMID: 39914530
Liposomal vaccines have been developed extensively in recent years, and considerable progress has been made in the prevention of infectious diseases. Quaternary chitosan-coated liposomes were used in the present study....
2.
Liu P, Chang T, Chen X, Cheng C, Huang C, Chen A, et al.
Int J Biol Macromol
. 2024 Nov;
284(Pt 1):137996.
PMID: 39586441
This study introduced a novel antiviral approach by combining three substances with different antiviral mechanisms: N-(2-hydroxy)propyl-3-trimethylammoniumchitosan (HTC), silver nanoparticles (AgNPs), and oseltamivir. First, positively surface-charged AgNPs were prepared using an...
3.
Chen X, Chuang C, Chen C, Lee C, Chin C, Young J, et al.
Colloids Surf B Biointerfaces
. 2024 Jun;
241:114030.
PMID: 38901267
To enhance the cellular uptake of liposomes, we prepared conventional liposomes with targeting molecules and surface-charged liposomes and evaluated their potential as nano-carriers and vaccine adjuvants by comparing their endocytosis...
4.
Bai B, Wang T, Chen X, Wu C
RSC Adv
. 2023 Nov;
13(45):31602-31615.
PMID: 37908665
There is a need for non-pharmaceutical intervention methods that can prevent and indicate the risk of airborne disease spread. In this study, we developed a nonwoven mat based on the...
5.
Chen C, Chen Y, Yeh C, Hsu C, Yu S, Hsu C, et al.
Front Pharmacol
. 2021 Dec;
12:746496.
PMID: 34899300
Tuberculosis (TB) is a leading cause of death from a single infectious agent, (). Although progress has been made in TB control, still about 10 million people worldwide develop TB...
6.
Lin H, Chen C, Chiao D, Chang T, Chen X, Young J, et al.
Int J Biol Macromol
. 2021 Nov;
193(Pt B):1885-1897.
PMID: 34774590
The spike (S) protein is a leading vaccine candidate against SARS-CoV-2 infection. The S1 domain of S protein, which contains a critical receptor-binding domain (RBD) antigen, potentially induces protective immunoreactivities...
7.
Tsai M, Chuang C, Chen C, Yen H, Cheng K, Chen X, et al.
Carbohydr Polym
. 2020 Mar;
236:116041.
PMID: 32172855
Fucoidan/trimethylchitosan nanoparticles (FUC-TMC-NPs) have the potential to improve the immunostimulating efficiency of anthrax vaccine adsorbed (AVA). FUC-TMC-NPs with positive (+) or negative (-) surface charges were prepared via polyelectrolyte complexation,...
8.
Chuang C, Tsai M, Yen H, Shyu H, Cheng K, Chen X, et al.
Carbohydr Polym
. 2019 Dec;
229:115403.
PMID: 31826481
We examined the efficacy of fucoidan-N-(2-hydroxy-3-trimethylammonium)propylchitosan nanoparticles (FUC-HTCC NPs) as adjuvants for anthrax vaccine adsorbed (AVA). Positively and negatively surface-charged FUC-HTCC NPs were prepared via polyelectrolyte complexation by varying the...
9.
Wang S, Chen C, Lee C, Chen X, Chang T, Cheng Y, et al.
Int J Biol Macromol
. 2019 Nov;
143:724-731.
PMID: 31734360
Herein, positively surface-charged silver nanoparticles (AgNPs) capped with trimethylchitosan nitrate (TMCN) were synthesized using an environmentally friendly method. Nano-sized TMCN-AgNPs (~80 nm) with high zeta potential (>30 mV) provide sufficient...
10.
Yen H, Young Y, Tsai T, Cheng K, Chen X, Chen Y, et al.
Carbohydr Polym
. 2018 Jan;
183:140-150.
PMID: 29352869
In this study, we synthesized various quaternary chitosan derivatives and used them to stabilize gold nanoparticles (AuNPs). These chitosan derivatives comprised N-(2-hydroxy)propyl-3-trimethylammonium chitosan chloride (HTCC), folate-HTCC, galactosyl-HTCC, and their fluorescein...