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Xiaolu Lei

Explore the profile of Xiaolu Lei including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 32
Followers 0
Related Specialties
Neurology
Chemistry
Pharmacology
Top 10 Co-Authors
Junwei Zeng
Xiaohong Liu
Yan Yan
Zhaoxiang Yang
Zhongqiu Liu
Rong Wang
Zheng Cai
Weifeng Yu
Yingfu Jiao
Huan Jin
Published In
Neurochem Res
J Drug Target
Neurochem Int
Acta Pharm Sin B
CNS Neurosci Ther
Affiliations
Soon will be listed here.
Recent Articles
1.
Parabrachial nucleus Vglut2 expressing neurons projection to the extended amygdala involved in the regulation of wakefulness during sevoflurane anesthesia in mice
Yan Y, Jiao Y, Liang E, Lei X, Zhang N, Xu S, et al.
CNS Neurosci Ther . 2024 Aug; 30(8):e70001. PMID: 39154359
Aims: The parabrachial nucleus (PBN) promotes wakefulness states under general anesthesia. Recent studies have shown that glutamatergic neurons within the PBN play a crucial role in facilitating emergence from anesthesia....
2.
Activation of HCN channels caused by elevated cAMP levels in periaqueductal gray promotes bone cancer pain
Lei X, Yan Y, Zeng J, Wang R, Li S, Xiao Z, et al.
Neurochem Int . 2022 Nov; 162:105437. PMID: 36336089
The periaqueductal gray (PAG) is an important relay center for the descending pathways that regulate nociceptive information transduction. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play critical roles in the nerve injury-induced...
3.
MiR-29c Inhibits TNF-α-Induced ROS Production and Apoptosis in Mouse Hippocampal HT22 Cell Line
Li B, Lu Y, Wang R, Xu T, Lei X, Jin H, et al.
Neurochem Res . 2022 Oct; 48(2):519-536. PMID: 36309937
Recent reports have suggested that abnormal miR-29c expression in hippocampus have been implicated in the pathophysiology of some neurodegenerative and neuropsychiatric diseases. However, the underlying effect of miR-29c in regulating...
4.
Blockage of HCN Channels Inhibits the Function of P2X Receptors in Rat Dorsal Root Ganglion Neurons
Lei X, Zeng J, Yan Y, Liu X
Neurochem Res . 2022 Jan; 47(4):1083-1096. PMID: 35064517
Hyperpolarization-activated cyclic nucleotide-gated channels and purinergic P2X receptors play critical roles in the nerve injury-induced pain hypersensitivity. Both HCN channels and P2XR are expressed in dorsal root ganglia sensory neurons....
5.
CB Receptors Mediated Inhibition of ATP-Induced [Ca]i Increase in Cultured Rat Spinal Dorsal Horn Neurons
Long J, Lei X, Chen M, Yang S, Sun T, Zeng J, et al.
Neurochem Res . 2017 Nov; 43(2):267-275. PMID: 29127599
Spinal cannabinoid receptor 1 (CBR) and purinergic P2X receptors (P2XR) play a critical role in the process of pathological pain. Both CBR and P2XR are expressed in spinal dorsal horn...
6.
Preparation and evaluation of sustained-release solid dispersions co-loading gastrodin with borneol as an oral brain-targeting enhancer
Cai Z, Lei X, Lin Z, Zhao J, Wu F, Yang Z, et al.
Acta Pharm Sin B . 2015 Nov; 4(1):86-93. PMID: 26579369
Borneol is a traditional Chinese medicine that can promote drug absorption from the gastrointestinal tract and distribution to the brain. However, stomach irritation may occur when high doses of borneol...
7.
Role of glucose transporters in the intestinal absorption of gastrodin, a highly water-soluble drug with good oral bioavailability
Cai Z, Huang J, Luo H, Lei X, Yang Z, Mai Y, et al.
J Drug Target . 2013 Mar; 21(6):574-80. PMID: 23480725
Gastrodin, a sedative drug, is a highly water-soluble phenolic glucoside with poor liposolubility but exhibits good oral bioavailability. The current study aims to investigate whether glucose transporters (GLTs) are involved...