Xiaolin Charlie Tang
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Explore the profile of Xiaolin Charlie Tang including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
198
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Recent Articles
1.
Cheng Y, Duong H, Hu Q, Shameem M, Tang X
Antib Ther
. 2025 Jan;
8(1):13-25.
PMID: 39839910
The development of lyophilized protein drug products is a critical and complex task in the pharmaceutical industry, requiring a comprehensive understanding of the myriad of factors affecting product quality, stability,...
2.
Zhi L, Chen Y, Lai K, Wert J, Li S, Wang X, et al.
Int J Pharm
. 2023 Nov;
648:123564.
PMID: 37914106
Recombinant adeno-associated virus (rAAV) has emerged as the leading gene delivery platform for treatment of monogenic disorders. Currently, for clinical and commercial products, rAAVs are typically formulated and stored below...
3.
Tang X, Nail S, Pikal M
AAPS PharmSciTech
. 2007 Feb;
7(4):97.
PMID: 17285746
This article evaluates the procedures for determining the vial heat transfer coefficient and the extent of primary drying through manometric temperature measurement (MTM). The vial heat transfer coefficients (Kv) were...
4.
Tang X, Nail S, Pikal M
AAPS PharmSciTech
. 2007 Feb;
7(4):93.
PMID: 17285744
The purpose of this work was to study the factors that may cause systematic errors in the manometric temperature measurement (MTM) procedure used to determine product dry-layer resistance to vapor...
5.
Tang X, Pikal M
Pharm Res
. 2005 Jul;
22(7):1176-85.
PMID: 16028019
Purpose: The aim of the study is to determine the degree of coupling between protein unfolding rate and system viscosity at low temperatures in systems relevant to freeze-drying. Methods: The...
6.
Tang X, Pikal M
Pharm Res
. 2005 Jul;
22(7):1167-75.
PMID: 16028018
Purpose: The aim of the study is to investigate the effects of stabilizers and denaturants on the thermal and cold denaturation temperatures of selected proteins in systems of interest to...
7.
Chang L, Shepherd D, Sun J, Ouellette D, Grant K, Tang X, et al.
J Pharm Sci
. 2005 May;
94(7):1427-44.
PMID: 15920775
The purpose of this study is to investigate the mechanism of protein stabilization by sugars in the solid state. That is, explore whether the stabilization is controlled by "glass dynamics"...
8.
Chang L, Shepherd D, Sun J, Tang X, Pikal M
J Pharm Sci
. 2005 May;
94(7):1445-55.
PMID: 15920766
Purpose: To investigate the effect of plasticizers on the stability of protein formulations in the solid state and to apply these results to a study of mechanisms of protein stabilization...
9.
Tang X, Nail S, Pikal M
Pharm Res
. 2005 May;
22(4):685-700.
PMID: 15889467
Purpose: To develop a procedure based on manometric temperature measurement (MTM) and an expert system for good practices in freeze drying that will allow development of an optimized freeze-drying process...
10.
Pikal M, Chang L, Tang X
J Pharm Sci
. 2004 Mar;
93(4):981-94.
PMID: 14999734
The purpose of this study is to investigate the quantitative relationship between the width of the glass transition, DeltaTg, and glass fragility or activation energy for structural relaxation. The ultimate...