Xianzun Tao
Overview
Explore the profile of Xianzun Tao including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
139
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0
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Recent Articles
1.
Lobato A, Ortiz-Vega N, Canic T, Tao X, Bucan N, Ruan K, et al.
Biochim Biophys Acta Mol Basis Dis
. 2024 Jul;
1870(7):167348.
PMID: 38986817
Hereditary Spastic Paraplegia (HSP) is a group of rare inherited disorders characterized by progressive weakness and spasticity of the legs. Recent newly discovered biallelic variants in the gene FICD were...
2.
Tao X, Liu J, Diaz-Perez Z, Foley J, Nwafor A, Stewart T, et al.
Cell Death Dis
. 2024 May;
15(5):333.
PMID: 38740758
Precise polyamine metabolism regulation is vital for cells and organisms. Mutations in spermine synthase (SMS) cause Snyder-Robinson intellectual disability syndrome (SRS), characterized by significant spermidine accumulation and autophagy blockage in...
3.
Stewart T, Foley J, Holbert C, Khomutov M, Rastkari N, Tao X, et al.
EMBO Mol Med
. 2023 Sep;
15(11):e17833.
PMID: 37702369
Snyder-Robinson syndrome (SRS) results from mutations in spermine synthase (SMS), which converts the polyamine spermidine into spermine. Affecting primarily males, common manifestations of SRS include intellectual disability, osteoporosis, hypotonia, and...
4.
Stewart T, Foley J, Holbert C, Khomutov M, Rastkari N, Tao X, et al.
bioRxiv
. 2023 Apr;
PMID: 37034775
Snyder-Robinson Syndrome (SRS) is caused by mutations in the spermine synthase (SMS) gene, the enzyme product of which converts the polyamine spermidine into spermine. Affecting primarily males, common manifestations of...
5.
Zhu Y, Lobato A, Rebelo A, Canic T, Ortiz-Vega N, Tao X, et al.
JCI Insight
. 2023 Apr;
8(10).
PMID: 37014713
Sorbitol dehydrogenase (SORD) deficiency has been identified as the most frequent autosomal recessive form of hereditary neuropathy. Loss of SORD causes high sorbitol levels in tissues due to the inability...
6.
Reduction of Spermine Synthase Suppresses Tau Accumulation Through Autophagy Modulation in Tauopathy
Tao X, Liu J, Diaz-Perez Z, Foley J, Stewart T, Casero Jr R, et al.
bioRxiv
. 2023 Mar;
PMID: 36993333
Tauopathy, including Alzheimer Disease (AD), is characterized by Tau protein accumulation and autophagy dysregulation. Emerging evidence connects polyamine metabolism with the autophagy pathway, however the role of polyamines in Tauopathy...
7.
Tao X, Zhu Y, Diaz-Perez Z, Yu S, Foley J, Stewart T, et al.
JCI Insight
. 2022 Jul;
7(13).
PMID: 35801587
Polyamine dysregulation plays key roles in a broad range of human diseases from cancer to neurodegeneration. Snyder-Robinson syndrome (SRS) is the first known genetic disorder of the polyamine pathway, caused...
8.
Liu J, Tao X, Zhu Y, Li C, Ruan K, Diaz-Perez Z, et al.
Elife
. 2021 Dec;
10.
PMID: 34919052
Gliomas are highly malignant brain tumors with poor prognosis and short survival. NAD has been shown to impact multiple processes that are dysregulated in cancer; however, anti-cancer therapies targeting NAD...
9.
Tantak M, Sekhar V, Tao X, Zhai R, Phanstiel 4th O
J Med Chem
. 2021 Oct;
64(21):15593-15607.
PMID: 34695351
Snyder Robinson Syndrome (SRS) is a rare disease associated with a defective spermine synthase gene and low intracellular spermine levels. In this study, a spermine replacement therapy was developed using...
10.
Park J, Zhu Y, Tao X, Brazill J, Li C, Wuchty S, et al.
iScience
. 2019 Sep;
19:1048-1064.
PMID: 31522116
Understanding endogenous regulation of stress resistance and homeostasis maintenance is critical to developing neuroprotective therapies. Nicotinamide mononucleotide adenylyltransferase (NMNAT) is a conserved essential enzyme that confers extraordinary protection and stress...