Xiangzhong Zheng
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Explore the profile of Xiangzhong Zheng including associated specialties, affiliations and a list of published articles.
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25
Citations
1344
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Recent Articles
1.
Zheng X, Chen D, Zoltowski B, Sehgal A
Sci Rep
. 2024 Oct;
14(1):26051.
PMID: 39472713
Drosophila Cryptochrome (CRY) is an essential photoreceptor that mediates the resetting of the circadian clock by light. in vitro studies demonstrated a critical role of redox cycling of the FAD...
2.
Zheng X
Cells
. 2024 Jul;
13(14.
PMID: 39056774
Studies on numerous species have demonstrated strikingly conserved mechanisms that determine the aging process, from yeasts to worms, flies, zebrafish, mice, and humans. The fruit fly is an excellent model...
3.
OHara M, Saul C, Handa A, Cho B, Zheng X, Sehgal A, et al.
Sleep
. 2024 Apr;
47(8).
PMID: 38629438
The nuclear factor binding the κ light chain in B-cells (NFκB) is involved in a wide range of cellular processes including development, growth, innate immunity, and sleep. However, genetic studies...
4.
Hsieh A, Zheng X, Yue Z, Stine Z, Mancuso A, Rhoades S, et al.
Cell Rep
. 2019 Nov;
29(7):1778-1788.e4.
PMID: 31722196
Drosophila Myc (dMyc) is highly conserved and functions as a transcription factor similar to mammalian Myc. We previously found that oncogenic Myc disrupts the molecular clock in cancer cells. Here,...
5.
Stone R, McGlinn A, Chakraborty R, Lee D, Yang V, Elmasri A, et al.
PLoS One
. 2019 Jun;
14(6):e0217111.
PMID: 31211778
The pathophysiology of refractive errors is poorly understood. Myopia (nearsightedness) in particular both blurs vision and predisposes the eye to many blinding diseases during adulthood. Based on past findings of...
6.
Bai L, Lee Y, Hsu C, Williams J, Cavanaugh D, Zheng X, et al.
Cell Rep
. 2018 Mar;
22(13):3416-3426.
PMID: 29590612
Loss of the Neurofibromatosis 1 (Nf1) protein, neurofibromin, in Drosophila disrupts circadian rhythms of locomotor activity without impairing central clock function, suggesting effects downstream of the clock. However, the relevant...
7.
Katewa S, Akagi K, Bose N, Rakshit K, Camarella T, Zheng X, et al.
Cell Metab
. 2015 Dec;
23(1):143-54.
PMID: 26626459
Endogenous circadian clocks orchestrate several metabolic and signaling pathways that are known to modulate lifespan, suggesting clocks as potential targets for manipulation of metabolism and lifespan. We report here that...
8.
Kumar S, Chen D, Jang C, Nall A, Zheng X, Sehgal A
Nat Commun
. 2014 Dec;
5:5697.
PMID: 25511299
Little is known about molecular links between circadian clocks and steroid hormone signalling, although both are important for normal physiology. Here we report a circadian function for a nuclear receptor,...
9.
Zheng X, Sowcik M, Chen D, Sehgal A
Mol Cell Biol
. 2014 May;
34(14):2682-94.
PMID: 24820422
Casein kinase 1, known as DOUBLETIME (DBT) in Drosophila melanogaster, is a critical component of the circadian clock that phosphorylates and promotes degradation of the PERIOD (PER) protein. However, other...
10.
Cavanaugh D, Geratowski J, Wooltorton J, Spaethling J, Hector C, Zheng X, et al.
Cell
. 2014 Apr;
157(3):689-701.
PMID: 24766812
Though much is known about the cellular and molecular components of the circadian clock, output pathways that couple clock cells to overt behaviors have not been identified. We conducted a...