Xiang-Ming Zha
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Explore the profile of Xiang-Ming Zha including associated specialties, affiliations and a list of published articles.
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36
Citations
1429
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Recent Articles
1.
Shore D, Griggs N, Graffeo V, Amin A, Zha X, Xu Y, et al.
Sci Rep
. 2023 Jan;
13(1):353.
PMID: 36611126
Head and neck cancer is the sixth most common malignancy, and there is an urgent need to identify physiological processes contributing to tumorigenesis. Extracellular acidification caused by aerobic glycolysis within...
2.
Zha X, Xiong Z, Simon R
J Cereb Blood Flow Metab
. 2022 Mar;
42(8):1349-1363.
PMID: 35301897
Extracellular proton concentration is at 40 nM when pH is 7.4. In disease conditions such as brain ischemia, proton concentration can reach µM range. To respond to this increase in...
3.
Zhou G, Zha X
Front Neurosci
. 2021 Jun;
15:692217.
PMID: 34113235
Persistent acidosis occurs in ischemia and multiple neurological diseases. In previous studies, acidic stimulation leads to rapid increase in intracellular calcium in neurons. However, it remains largely unclear how a...
4.
Zhou G, Wang T, Zha X
FASEB J
. 2021 Mar;
35(4):e21461.
PMID: 33724568
Brain acid signaling plays important roles in both physiological and disease conditions. One key neuronal metabotropic proton receptor in the brain is GPR68, which contributes to hippocampal long-term potentiation (LTP)...
5.
6.
Wang T, He M, Zha X
Brain Hemorrhages
. 2021 Feb;
1(4):185-191.
PMID: 33575546
Hemorrhagic transformation (HT) following ischemia is one complication which worsens stroke outcome. During and after ischemia-reperfusion, persistent reduction of brain pH occurs. In a recent study, we found that GPR68...
7.
Wang T, Zhou G, He M, Xu Y, Rusyniak W, Xu Y, et al.
Stroke
. 2020 Oct;
51(12):3690-3700.
PMID: 33059544
Background And Purpose: Brain acidosis is prevalent in stroke and other neurological diseases. Acidosis can have paradoxical injurious and protective effects. The purpose of this study is to determine whether...
8.
Xu Y, Lin M, Zha X
Mol Brain
. 2020 Sep;
13(1):132.
PMID: 32993733
Increased neural activities reduced pH at the synaptic cleft and interstitial spaces. Recent studies have shown that protons function as a neurotransmitter. However, it remains unclear whether protons signal through...
9.
Jiang Q, Peterson A, Chu Y, Yao X, Zha X, Chu X
Biomolecules
. 2020 Sep;
10(9).
PMID: 32887365
Acid-sensing ion channel (ASIC) subunits 1a and 3 are highly expressed in central and peripheral sensory neurons, respectively. Endogenous biomolecule zinc plays a critical role in physiological and pathophysiological conditions....
10.
Yang J, Qiu L, Strobel M, Kabel A, Zha X, Chen X
Mol Neurobiol
. 2020 May;
57(7):3042-3056.
PMID: 32458389
Acids can disturb the ecosystem of wild animals through altering their olfaction and olfaction-related survival behaviors. It is known that the main olfactory epithelia (MOE) of mammals rely on odorant...