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Xian K Zhang

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Articles 20
Citations 328
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Recent Articles
1.
Wang X, Richard M, Caldwell T, Sundararaj K, Sato S, Nowling T, et al.
Front Immunol . 2023 Oct; 14:1219279. PMID: 37790939
The transcription factor Fli-1, a member of the ETS family of transcription factors, is implicated in the pathogenesis of lupus disease. Reduced Fli-1 expression in lupus mice leads to decreased...
2.
Sato S, Zhang X, Matsuoka N, Sumichika Y, Saito K, Yoshida S, et al.
Lupus Sci Med . 2023 Apr; 10(1). PMID: 37094946
Objective: Friend leukaemia virus integration 1 (Fli-1) regulates chemokine/cytokine expression and thus plays an important role in the development of lupus nephritis. Chemokine CXC ligand 13 (CXCL13) is a chemokine...
3.
Suzuki E, Zhang X, Yashiro-Furuya M, Asano T, Kanno T, Kobayashi H, et al.
Medicine (Baltimore) . 2022 Nov; 101(45):e31522. PMID: 36397345
Transcription factors E26 transformation-specific-1 (Ets-1) and Friend leukemia insertion site-1 (Fli-1) and type I interferon (IFN) have been implicated in systemic lupus erythematosus (SLE). We examined the expression of these...
4.
Wang X, Oates J, Helke K, Gilkeson G, Zhang X
Arthritis Rheumatol . 2021 Feb; 73(8):1478-1488. PMID: 33559345
Objective: To examine the therapeutic effects of camptothecin (CPT) and topotecan (TPT), inhibitors of transcription factor Fli-1 and topoisomerase, on lupus nephritis in (NZB × NZW)F1 (NZBWF1) mice, and to...
5.
Wang X, Richard M, Li P, Henry B, Schutt S, Yu X, et al.
J Immunol . 2020 Dec; 206(1):59-66. PMID: 33268481
Friend leukemia virus integration 1 (Fli-1) is an ETS transcription factor and a critical regulator of inflammatory mediators, including MCP-1, CCL5, IL-6, G-CSF, CXCL2, and caspase-1. GM-CSF is a regulator...
6.
Sato S, Zhang X, Temmoku J, Fujita Y, Matsuoka N, Yashiro-Furuya M, et al.
Cells . 2020 Mar; 9(3). PMID: 32183259
The transcription factor Friend leukemia integration 1 (Fli-1) regulates the expression of numerous cytokines and chemokines and alters the progression of lupus nephritis in humans and in the MRL/MpJ- (MRL/lpr)...
7.
Li P, Goodwin A, Cook J, Halushka P, Zhang X, Fan H
Mol Immunol . 2019 Feb; 108:1-7. PMID: 30739075
Our previous data demonstrated that Friend leukemia virus integration 1 (Fli-1), an ETS transcription factor, governs pericyte loss and vascular dysfunction in cecal ligation and puncture-induced murine sepsis by regulating...
8.
Li P, Zhou Y, Goodwin A, Cook J, Halushka P, Zhang X, et al.
J Infect Dis . 2018 Jul; 218(12):1995-2005. PMID: 30053030
Background: Pericytes are vascular mural cells and are embedded in the basement membrane of the microvasculature. Recent studies suggest a role for pericytes in lipopolysaccharide (LPS)-induced microvascular dysfunction and mortality,...
9.
Lou N, Lennard Richard M, Yu J, Kindy M, Zhang X
Mol Immunol . 2016 Nov; 81:59-66. PMID: 27889620
Mammalian cells produce inflammatory cytokines and chemokines in response to innate immune signals and their expression is tightly regulated. Chemokine (C-X-C motif) ligand 2 (CXCL2), also known as macrophage inflammatory...
10.
Lennard Richard M, Brandon D, Lou N, Sato S, Caldwell T, Nowling T, et al.
Eur J Immunol . 2016 Jul; 46(10):2322-2332. PMID: 27431361
Fli-1 has emerged as a critical regulator of inflammatory mediators, including MCP-1, CCL5, and IL-6. The cytokine, granulocyte colony stimulating factor (G-CSF) regulates neutrophil precursor maturation and survival, and activates...