Xavier Salvatella
Overview
Explore the profile of Xavier Salvatella including associated specialties, affiliations and a list of published articles.
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86
Citations
2631
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Recent Articles
1.
Catala-Castro F, Ortiz-Vasquez S, Martinez-Fernandez C, Pezzano F, Garcia-Cabau C, Fernandez-Campo M, et al.
Nat Nanotechnol
. 2025 Jan;
PMID: 39747604
Quantifying the mechanical response of the biological milieu (such as the cell's interior) and complex fluids (such as biomolecular condensates) would enable a better understanding of cellular differentiation and aging...
2.
Garcia-Cabau C, Bartomeu A, Tesei G, Cheung K, Pose-Utrilla J, Pico S, et al.
Nature
. 2024 Dec;
637(8045):496-503.
PMID: 39633052
The inclusion of microexons by alternative splicing occurs frequently in neuronal proteins. The roles of these sequences are largely unknown, and changes in their degree of inclusion are associated with...
3.
Lujan P, Garcia-Cabau C, Wakana Y, Lillo J, Rodilla-Ramirez C, Sugiura H, et al.
Elife
. 2024 Mar;
12.
PMID: 38466628
Secretory proteins are sorted at the -Golgi network (TGN) for export into specific transport carriers. However, the molecular players involved in this fundamental process remain largely elusive. Here, we identified...
4.
Neeb A, Figueiredo I, Bogdan D, Cato L, Stober J, Jimenez-Vacas J, et al.
Mol Cancer Ther
. 2024 Feb;
23(6):791-808.
PMID: 38412481
Therapies that abrogate persistent androgen receptor (AR) signaling in castration-resistant prostate cancer (CRPC) remain an unmet clinical need. The N-terminal domain of the AR that drives transcriptional activity in CRPC...
5.
Basu S, Martinez-Cristobal P, Frigole-Vivas M, Pesarrodona M, Lewis M, Szulc E, et al.
Nat Struct Mol Biol
. 2023 Dec;
30(12):1958-1969.
PMID: 38049566
Transcription factors are among the most attractive therapeutic targets but are considered largely 'undruggable' in part due to the intrinsically disordered nature of their activation domains. Here we show that...
6.
Sanfeliu-Cerdan N, Catala-Castro F, Mateos B, Garcia-Cabau C, Ribera M, Ruider I, et al.
Nat Cell Biol
. 2023 Oct;
25(11):1590-1599.
PMID: 37857834
A growing body of work suggests that the material properties of biomolecular condensates ensuing from liquid-liquid phase separation change with time. How this aging process is controlled and whether the...
7.
Christou-Kent M, Cuartero S, Garcia-Cabau C, Ruehle J, Naderi J, Erber J, et al.
Cell Rep
. 2023 Jul;
42(8):112897.
PMID: 37516962
Cell identity is orchestrated through an interplay between transcription factor (TF) action and genome architecture. The mechanisms used by TFs to shape three-dimensional (3D) genome organization remain incompletely understood. Here...
8.
Lewis M, Terre B, Knobel P, Cheng T, Lu H, Stephan-Otto Attolini C, et al.
Cell Death Dis
. 2023 Mar;
14(3):201.
PMID: 36932059
Multiciliated cells (MCCs) project dozens to hundreds of motile cilia from their apical surface to promote the movement of fluids or gametes in the mammalian brain, airway or reproductive organs....
9.
Mensah M, Niskanen H, Magalhaes A, Basu S, Kircher M, Sczakiel H, et al.
Nature
. 2023 Feb;
614(7948):564-571.
PMID: 36755093
Thousands of genetic variants in protein-coding genes have been linked to disease. However, the functional impact of most variants is unknown as they occur within intrinsically disordered protein regions that...
10.
Natera-de Benito D, Olival J, Garcia-Cabau C, Jou C, Roldan M, Codina A, et al.
Ann Clin Transl Neurol
. 2023 Jan;
10(3):408-425.
PMID: 36651622
Objective: Mutations in ANXA11 cause amyotrophic lateral sclerosis (ALS) and have recently been identified as a cause of multisystem proteinopathy and adult-onset muscular dystrophy. These conditions are adult-onset diseases and...