Xavier Rovira
Overview
Explore the profile of Xavier Rovira including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
616
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Recent Articles
1.
Notartomaso S, Antenucci N, Mazzitelli M, Rovira X, Boccella S, Ricciardi F, et al.
Elife
. 2024 Aug;
13.
PMID: 39172042
We used light-sensitive drugs to identify the brain region-specific role of mGlu5 metabotropic glutamate receptors in the control of pain. Optical activation of systemic JF-NP-26, a caged, normally inactive, negative...
2.
Panarello S, Gonzalez-Diez A, Berizzi A, Malhaire F, Borras-Tuduri R, Rovira X, et al.
iScience
. 2024 Jul;
27(6):110123.
PMID: 38966572
Metabotropic glutamate receptors (mGlu) regulate multiple functions in the nervous systems and are involved in several neurological disorders. However, selectively targeting individual mGlu subtypes with spatiotemporal precision is still an...
3.
Notartomaso S, Antenucci N, Mazzitelli M, Rovira X, Boccella S, Ricciardi F, et al.
bioRxiv
. 2024 Jan;
PMID: 38260426
Knowing the site of drug action is important to optimize effectiveness and address any side effects. We used light-sensitive drugs to identify the brain region-specific role of mGlu5 metabotropic glutamate...
4.
Lecat-Guillet N, Quast R, Liu H, Bourrier E, Moller T, Rovira X, et al.
Sci Adv
. 2023 Jun;
9(22):eadf1378.
PMID: 37267369
Allosteric modulators bear great potential to fine-tune neurotransmitter action. Promising targets are metabotropic glutamate (mGlu) receptors, which are associated with numerous brain diseases. Orthosteric and allosteric ligands act in synergy...
5.
Arias-Cabrales C, Folgueiras M, Faura A, Eguia J, Padilla E, Hurtado S, et al.
Transplantation
. 2022 Dec;
107(2):457-465.
PMID: 36584381
Background: The original SARS-CoV-2 vaccination regimen (2 doses) induces insufficient short-term response in kidney transplant (KT) recipients. This study assessed the response to a third dose and the long-term immunogenicity...
6.
Duran-Corbera A, Font J, Faria M, Prats E, Consegal M, Catena J, et al.
iScience
. 2022 Oct;
25(10):105128.
PMID: 36185381
Adrenoceptors are G protein-coupled receptors involved in a large variety of physiological processes, also under pathological conditions. This is due in large part to their ubiquitous expression in the body...
7.
Gomez-Santacana X, Panarello S, Rovira X, Llebaria A
Curr Opin Pharmacol
. 2022 Jul;
66:102266.
PMID: 35870289
Metabotropic glutamate receptors (mGlu) are a family of class C G protein-coupled receptors (GPCRs) with important biological functions and widespread expression. The mechanisms of mGlu activation and the development of...
8.
Duran-Corbera A, Faria M, Ma Y, Prats E, Dias A, Catena J, et al.
Angew Chem Int Ed Engl
. 2022 May;
61(30):e202203449.
PMID: 35608051
Catecholamine-triggered β-adrenoceptor (β-AR) signaling is essential for the correct functioning of the heart. Although both β - and β -AR subtypes are expressed in cardiomyocytes, drugs selectively targeting β -AR...
9.
Faria M, Bellot M, Bedrossiantz J, Ramirez J, Prats E, Garcia-Reyero N, et al.
J Hazard Mater
. 2022 Mar;
431:128563.
PMID: 35248961
The insecticide carbaryl is commonly found in indirectly exposed freshwater ecosystems at low concentrations considered safe for fish communities. In this study, we showed that after only 24 h of...
10.
Liu L, Fan Z, Rovira X, Xue L, Roux S, Brabet I, et al.
Elife
. 2021 Dec;
10.
PMID: 34866572
G protein-coupled receptors (GPCRs) are among the most promising drug targets. They often form homo- and heterodimers with allosteric cross-talk between receptor entities, which contributes to fine-tuning of transmembrane signaling....