Xander Spotbeen
Overview
Explore the profile of Xander Spotbeen including associated specialties, affiliations and a list of published articles.
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8
Citations
96
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0
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Recent Articles
1.
Kiviaho A, Eerola S, Kallio H, Andersen M, Hoikka M, Tiihonen A, et al.
Nat Commun
. 2024 Nov;
15(1):9949.
PMID: 39550375
Prostate cancer treatment resistance is a significant challenge facing the field. Genomic and transcriptomic profiling have partially elucidated the mechanisms through which cancer cells escape treatment, but their relation toward...
2.
More S, Bonnereau J, Wouters D, Spotbeen X, Karras P, Rizzollo F, et al.
Sci Adv
. 2024 Oct;
10(42):eadp6164.
PMID: 39413195
A major therapeutic barrier in melanoma is the coexistence of diverse cellular states marked by distinct metabolic traits. Transitioning from a proliferative to an invasive melanoma phenotype is coupled with...
3.
de Laat V, Topal H, Spotbeen X, Talebi A, Dehairs J, Idkowiak J, et al.
Nat Commun
. 2024 Oct;
15(1):8540.
PMID: 39358362
A spontaneously occurring temperature increase in solid tumors has been reported sporadically, but is largely overlooked in terms of cancer biology. Here we show that temperature is increased in tumors...
4.
Talebi A, de Laat V, Spotbeen X, Dehairs J, Rambow F, Rogiers A, et al.
J Exp Clin Cancer Res
. 2023 Apr;
42(1):92.
PMID: 37072838
Background: One of the key limitations of targeted cancer therapies is the rapid onset of therapy resistance. Taking BRAF-mutant melanoma as paradigm, we previously identified the lipogenic regulator SREBP-1 as...
5.
Altea-Manzano P, Doglioni G, Liu Y, Cuadros A, Nolan E, Fernandez-Garcia J, et al.
Nat Cancer
. 2023 Feb;
4(3):344-364.
PMID: 36732635
Metabolic rewiring is often considered an adaptive pressure limiting metastasis formation; however, some nutrients available at distant organs may inherently promote metastatic growth. We find that the lung and liver...
6.
Unravelling Prostate Cancer Heterogeneity Using Spatial Approaches to Lipidomics and Transcriptomics
Mutuku S, Spotbeen X, Trim P, Snel M, Butler L, Swinnen J
Cancers (Basel)
. 2022 Apr;
14(7).
PMID: 35406474
Due to advances in the detection and management of prostate cancer over the past 20 years, most cases of localised disease are now potentially curable by surgery or radiotherapy, or...
7.
Butler L, Mah C, Machiels J, Vincent A, Irani S, Mutuku S, et al.
Cancer Res
. 2021 Aug;
81(19):4981-4993.
PMID: 34362796
Dysregulated lipid metabolism is a prominent feature of prostate cancer that is driven by androgen receptor (AR) signaling. Here we used quantitative mass spectrometry to define the "lipidome" in prostate...
8.
Truong J, Spotbeen X, White J, Swinnen J, Butler L, Snel M, et al.
Anal Bioanal Chem
. 2021 Feb;
413(10):2695-2708.
PMID: 33564925
Matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) is a common molecular imaging modality used to characterise the abundance and spatial distribution of lipids in situ. There are several technical challenges...