Wolfgang Kastenmuller
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Explore the profile of Wolfgang Kastenmuller including associated specialties, affiliations and a list of published articles.
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74
Citations
6333
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Recent Articles
1.
Ehlers G, Todtmann A, Holsten L, Willers M, Heckmann J, Schoning J, et al.
Nat Commun
. 2025 Mar;
16(1):2239.
PMID: 40050264
Neonates primarily rely on innate immune defense, yet their inflammatory responses are usually restricted compared to adults. This is controversially interpreted as a sign of immaturity or essential programming, increasing...
2.
Yaniv Z, Anidi I, Arakkal L, Arroyo-Mejias A, Beuschel R, Borner K, et al.
ArXiv
. 2025 Jan;
PMID: 39764400
The iterative bleaching extends multiplexity (IBEX) Knowledge-Base is a central portal for researchers adopting IBEX and related 2D and 3D immunofluorescence imaging methods. The design of the Knowledge-Base is modeled...
3.
Radtke A, Anidi I, Arakkal L, Arroyo-Mejias A, Beuschel R, Borner K, et al.
ArXiv
. 2024 Oct;
PMID: 39398203
Iterative Bleaching Extends multipleXity (IBEX) is a versatile method for highly multiplexed imaging of diverse tissues. Based on open science principles, we created the IBEX Knowledge-Base, a resource for reagents,...
4.
You Y, Dunst J, Ye K, Sandoz P, Reinhardt A, Sandrock I, et al.
Nat Immunol
. 2024 Jul;
25(8):1367-1382.
PMID: 38992254
Upregulation of diverse self-antigens that constitute components of the inflammatory response overlaps spatially and temporally with the emergence of pathogen-derived foreign antigens. Therefore, discrimination between these inflammation-associated self-antigens and pathogen-derived...
5.
Schafer S, Gogiraju R, Rosch M, Kerstan Y, Beck L, Garbisch J, et al.
Arterioscler Thromb Vasc Biol
. 2024 Jun;
44(8):1852-1872.
PMID: 38868941
Background: Atherosclerosis is driven by the infiltration of the arterial intima by diverse immune cells and smooth muscle cells (SMCs). CD8 T cells promote lesion growth during atherosclerotic lesion development,...
6.
Oberkircher L, Scheiding V, Rafeld H, Hanssen E, Hansen J, Fleischmann M, et al.
Mucosal Immunol
. 2024 May;
17(5):777-792.
PMID: 38750967
The immune response against Legionella longbeachae, a causative agent of the often-fatal Legionnaires' pneumonia, is poorly understood. Here, we investigated the specific roles of tissue-resident alveolar macrophages (AMs) and infiltrating...
7.
Torcellan T, Friedrich C, Doucet-Ladeveze R, Ossner T, Sole V, Riedmann S, et al.
Immunity
. 2023 Dec;
57(1):124-140.e7.
PMID: 38157853
Natural killer (NK) cells are present in the circulation and can also be found residing in tissues, and these populations exhibit distinct developmental requirements and are thought to differ in...
8.
Cruz de Casas P, Knopper K, Sarkar R, Kastenmuller W
Nat Rev Immunol
. 2023 Dec;
24(5):358-374.
PMID: 38097778
Lymph nodes are secondary lymphoid organs in which immune responses of the adaptive immune system are initiated and regulated. Distributed throughout the body and embedded in the lymphatic system, local...
9.
Wu H, Zhao X, Hochrein S, Eckstein M, Gubert G, Knopper K, et al.
Nat Commun
. 2023 Oct;
14(1):6858.
PMID: 37891230
T cell exhaustion is a hallmark of cancer and persistent infections, marked by inhibitory receptor upregulation, diminished cytokine secretion, and impaired cytolytic activity. Terminally exhausted T cells are steadily replenished...
10.
Kaminski A, Hager F, Kopplin L, Ticconi F, Leufgen A, Vendelova E, et al.
Sci Immunol
. 2023 Oct;
8(89):eadj5789.
PMID: 37874251
Regulatory T cells (T) are present in lymphoid and nonlymphoid tissues where they restrict immune activation, prevent autoimmunity, and regulate inflammation. T in nonlymphoid tissues are typically resident, whereas those...