Wilton B Williams
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Explore the profile of Wilton B Williams including associated specialties, affiliations and a list of published articles.
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34
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949
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Recent Articles
1.
Holmes S, Li H, Shen X, Martin M, Tuck R, Chen Y, et al.
Nat Commun
. 2024 Nov;
15(1):10302.
PMID: 39604409
The details of the pediatric immune system that supports induction of antibodies capable of neutralizing geographically-diverse or heterologous HIV-1 is currently unclear. Here we explore the pediatric immune environment in...
2.
Violari A, Otwombe K, Hahn W, Chen S, Josipovic D, Baba V, et al.
medRxiv
. 2024 Nov;
PMID: 39484284
Background: The neonatal immune system is uniquely poised to generate broadly neutralizing antibodies (bnAbs) and thus infants are ideal for evaluating HIV vaccine candidates. We present the design and safety...
3.
Nelson A, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, et al.
Sci Immunol
. 2024 Aug;
9(98):eadm7097.
PMID: 39213340
Adolescents are a growing population of people living with HIV. The period between weaning and sexual debut presents a low-risk window for HIV acquisition, making early childhood an ideal time...
4.
Giorgi E, Li H, Hora B, Shaw G, Wagh K, Williams W
Viruses
. 2024 Jul;
16(7).
PMID: 39066177
We recently demonstrated that Simian-HIV (SHIV)-infected neonate rhesus macaques (RMs) generated heterologous HIV-1 neutralizing antibodies (NAbs) with broadly-NAb (bNAb) characteristics at a higher frequency compared with their corresponding dam. Here,...
5.
Zhang Q, Lindenberger J, Parsons R, Thakur B, Parks R, Park C, et al.
Mol Cell
. 2024 Jul;
84(14):2747-2764.e7.
PMID: 39059371
A recombinant lineage of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant, named XBB, appeared in late 2022 and evolved descendants that successively swept local and global populations....
6.
Williams W, Alam S, Ofek G, Erdmann N, Montefiori D, Seaman M, et al.
Cell
. 2024 May;
187(12):2919-2934.e20.
PMID: 38761800
A critical roadblock to HIV vaccine development is the inability to induce B cell lineages of broadly neutralizing antibodies (bnAbs) in humans. In people living with HIV-1, bnAbs take years...
7.
Wiehe K, Saunders K, Stalls V, Cain D, Venkatayogi S, Martin Beem J, et al.
Cell Host Microbe
. 2024 Apr;
32(5):693-709.e7.
PMID: 38670093
A major goal of HIV-1 vaccine development is the induction of broadly neutralizing antibodies (bnAbs). Although success has been achieved in initiating bnAb B cell lineages, design of boosting immunogens...
8.
Erdmann N, Williams W, Walsh S, Grunenberg N, Edlefsen P, Goepfert P, et al.
medRxiv
. 2024 Apr;
PMID: 38562833
Background: HIV-1 vaccine development is a global health priority. Broadly neutralizing antibodies (bnAbs) which target the HIV-1 gp41 membrane-proximal external region (MPER) have some of the highest neutralization breadth. An...
9.
Zhang Q, Lindenberger J, Parsons R, Thakur B, Parks R, Park C, et al.
bioRxiv
. 2024 Feb;
PMID: 38405707
A recombinant lineage of the SARS-CoV-2 Omicron variant, named XBB, appeared in late 2022 and evolved descendants that successively swept local and global populations. XBB lineage members were noted for...
10.
Saunders K, Counts J, Thakur B, Stalls V, Edwards R, Manne K, et al.
Cell
. 2024 Jan;
187(1):79-94.e24.
PMID: 38181743
The CD4-binding site (CD4bs) is a conserved epitope on HIV-1 envelope (Env) that can be targeted by protective broadly neutralizing antibodies (bnAbs). HIV-1 vaccines have not elicited CD4bs bnAbs for...