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William R Randall

Explore the profile of William R Randall including associated specialties, affiliations and a list of published articles. Areas
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Articles 21
Citations 561
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Recent Articles
1.
Burke R, Todd S, Lumsden E, Mullins R, Mamczarz J, Fawcett W, et al.
J Neurochem . 2017 Aug; 142 Suppl 2:162-177. PMID: 28791702
Organophosphorus (OP) insecticides are pest-control agents heavily used worldwide. Unfortunately, they are also well known for the toxic effects that they can trigger in humans. Clinical manifestations of an acute...
2.
Alkondon M, Pereira E, Todd S, Randall W, Lane M, Albuquerque E
Biochem Pharmacol . 2014 Dec; 93(4):506-18. PMID: 25542997
The G-protein-coupled receptor 35 (GPR35) was de-orphanized after the discovery that kynurenic acid (KYNA), an endogenous tryptophan metabolite, acts as an agonist of this receptor. Abundant evidence supports that GPR35...
3.
Liu Y, Hernandez-Ochoa E, Randall W, Schneider M
Am J Physiol Cell Physiol . 2012 Jun; 303(3):C334-47. PMID: 22648949
Reactive oxygen species (ROS) have been linked to oxidation and nuclear efflux of class IIa histone deacetylase 4 (HDAC4) in cardiac muscle. Here we use HDAC-GFP fusion proteins expressed in...
4.
Ackermann M, Ziman A, Strong J, Zhang Y, Hartford A, Ward C, et al.
J Cell Sci . 2011 Nov; 124(Pt 21):3619-30. PMID: 22045734
Small ankyrin 1 (sAnk1; Ank1.5) is a ~20 kDa protein of striated muscle that concentrates in the network compartment of the sarcoplasmic reticulum (nSR). We used siRNA targeted to sAnk1...
5.
Shen T, Liu Y, Contreras M, Hernandez-Ochoa E, Randall W, Schneider M
Histochem Cell Biol . 2010 Sep; 134(4):387-402. PMID: 20865272
We have previously demonstrated that Ca²+/calcineurin-dependent dephosphorylation of the transcription factor nuclear factor of activated T cells subtype 1 (NFATc1) during repetitive skeletal muscle activity causes NFAT nuclear translocation and...
6.
Zhang Y, Resneck W, Lee P, Randall W, Bloch R, Ursitti J
J Mol Cell Cardiol . 2010 Feb; 48(6):1050-9. PMID: 20114050
Spectrin is a large, flexible protein that stabilizes membranes and organizes proteins and lipids into microdomains in intracellular organelles and at the plasma membrane. Alternative splicing occurs in spectrins, but...
7.
Li H, Randall W, Du S
FASEB J . 2009 Feb; 23(6):1988-2000. PMID: 19211926
Myofibrillogenesis, the precise assembly of sarcomeric proteins into the highly organized sarcomeres, is essential for muscle cell differentiation and function. Myofibrillogenesis requires proper folding and assembly of newly synthesized sarcomeric...
8.
Liu Y, Contreras M, Shen T, Randall W, Schneider M
J Physiol . 2009 Jan; 587(Pt 5):1101-15. PMID: 19124542
The protein kinase PKD1 has recently been linked to slow fibre-type gene expression in fast skeletal muscle through phosphorylation of class II histone deacetylase (HDAC) molecules, resulting in nuclear efflux...
9.
Bowman A, Catino D, Strong J, Randall W, Kontrogianni-Konstantopoulos A, Bloch R
Mol Biol Cell . 2008 Jun; 19(9):3782-92. PMID: 18579686
Obscurin is an approximately 800-kDa protein composed of structural and signaling domains that organizes contractile structures in striated muscle. We have studied the Rho-GEF domain of obscurin to understand its...
10.
Ursitti J, Petrich B, Lee P, Resneck W, Ye X, Yang J, et al.
J Mol Cell Cardiol . 2007 Feb; 42(3):572-81. PMID: 17276456
Decreases in the expression of connexin 43 and the integrity of gap junctions in cardiac muscle, induced by the constitutive activation of the c-Jun N-terminal kinase (JNK) signaling pathway, have...