William P J Leenders
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Explore the profile of William P J Leenders including associated specialties, affiliations and a list of published articles.
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62
Citations
1300
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Recent Articles
1.
Visser W, de Jong H, Smit F, Shrivastava J, Poole J, Leenders W, et al.
Int J Mol Sci
. 2024 Nov;
25(22).
PMID: 39595976
Microarray and Single-Molecule Molecular Inversion Probe (smMIP)-based targeted RNA sequencing are two RNA profiling platforms for identifying disease-associated biomarkers. The microarray uses a GeneChip array with oligonucleotide probes to measure...
2.
Kwinten K, Lemain V, de Hullu J, Leenders W, Steenbeek M, Van Altena A, et al.
Cancer Med
. 2024 Jul;
13(14):e70000.
PMID: 39031958
Background: In the last decade, technical innovations have resulted in the development of several minimally invasive diagnostic cancer tools. Within women at high risk of developing ovarian or endometrial cancer...
3.
Molina M, Leenders W, Huynen M, Melchers W, Andralojc K
BMC Infect Dis
. 2024 Jun;
24(1):552.
PMID: 38831406
Background: Persistent infections with high-risk human papillomavirus (hrHPV) can cause cervical squamous intraepithelial lesions (SIL) that may progress to cancer. The cervicovaginal microbiome (CVM) correlates with SIL, but the temporal...
4.
Longitudinal analysis on the ecological dynamics of the cervicovaginal microbiome in hrHPV infection
Molina M, Melchers W, Andralojc K, Leenders W, Huynen M
Comput Struct Biotechnol J
. 2023 Sep;
21:4424-4431.
PMID: 37731597
The cervicovaginal microbiome (CVM) is a dynamic continuous microenvironment that can be clustered in microbial community state types (CSTs) and is associated with women's cervical health. -depleted communities particularly associate...
5.
van Lith S, Pruis I, Tolboom N, Snijders T, Henssen D, Laan M, et al.
J Nucl Med
. 2023 Aug;
64(10):1526-1531.
PMID: 37652540
Upregulation of prostate-specific membrane antigen (PSMA) in neovasculature has been described in glioblastoma multiforme (GBM), whereas vasculature in nonaffected brain shows hardly any expression of PSMA. It is unclear whether...
6.
Light-Responsive Elastin-Like Peptide-Based Targeted Nanoparticles for Enhanced Spheroid Penetration
Le D, Ibrahimova V, van den Wildenberg S, Wu H, Fonseca A, Torres T, et al.
Angew Chem Int Ed Engl
. 2023 Apr;
62(24):e202300511.
PMID: 37083071
We describe here a near infrared light-responsive elastin-like peptide (ELP)-based targeted nanoparticle (NP) that can rapidly switch its size from 120 to 25 nm upon photo-irradiation. Interestingly, the targeting function,...
7.
Molina M, Andralojc K, Huynen M, Leenders W, Melchers W
NPJ Biofilms Microbiomes
. 2022 Sep;
8(1):75.
PMID: 36171433
The cervicovaginal microbiome (CVM) correlates with women's cervical health, and variations in its composition are associated with high-risk human papillomavirus (hrHPV) infection outcomes. Cervicovaginal microbes have been grouped into five...
8.
In t Veld S, Arkani M, Post E, Antunes-Ferreira M, DAmbrosi S, Vessies D, et al.
Cancer Cell
. 2022 Sep;
40(9):999-1009.e6.
PMID: 36055228
Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for...
9.
Molina M, Coenen B, Leenders W, Andralojc K, Huynen M, Melchers W
mBio
. 2022 Aug;
13(5):e0161922.
PMID: 35980030
Cervical cancer is the third leading cause of female cancers globally, resulting in more than 300,000 deaths every year. The majority of all cervical cancers are caused by persistent infections...
10.
Andralojc K, Elmelik D, Rasing M, Pater B, Siebers A, Bekkers R, et al.
BMC Med
. 2022 Jun;
20(1):206.
PMID: 35676700
Background: Because most cervical cancers are caused by high-risk human papillomaviruses (hrHPVs), cervical cancer prevention programs increasingly employ hrHPV testing as a primary test. The high sensitivity of HPV tests...