William J Nicolas
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Explore the profile of William J Nicolas including associated specialties, affiliations and a list of published articles.
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19
Citations
273
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Recent Articles
1.
Nicolas W, Gillman C, Weaver S, Clabbers M, Shiriaeva A, Her A, et al.
Nat Protoc
. 2024 Dec;
PMID: 39706914
Microcrystal electron diffraction (MicroED) has advanced structural methods across a range of sample types, from small molecules to proteins. This cryogenic electron microscopy (cryo-EM) technique involves the continuous rotation of...
2.
Nicolas W, Shiriaeva A, Martynowycz M, Grey A, Ruma Y, Donaldson P, et al.
bioRxiv
. 2024 May;
PMID: 38798449
Human lens fiber membrane intrinsic protein MP20 is the second most abundant membrane protein of the human eye lens. Despite decades of effort its structure and function remained elusive. Here,...
3.
Shiriaeva A, Martynowycz M, Nicolas W, Cherezov V, Gonen T
bioRxiv
. 2023 Jul;
PMID: 37461729
The small size and flexibility of G protein-coupled receptors (GPCRs) have long posed a significant challenge to determining their structures for research and therapeutic applications. Single particle cryogenic electron microscopy...
4.
Kaplan M, Chang Y, Oikonomou C, Nicolas W, Jewett A, Kreida S, et al.
Nat Microbiol
. 2023 Jun;
8(7):1267-1279.
PMID: 37349588
Bdellovibrio bacteriovorus is a microbial predator that offers promise as a living antibiotic for its ability to kill Gram-negative bacteria, including human pathogens. Even after six decades of study, fundamental...
5.
Gillman C, Nicolas W, Martynowycz M, Gonen T
IUCrJ
. 2023 May;
10(Pt 4):430-436.
PMID: 37223996
In this work, a novel crystal growth method termed suspended drop crystallization has been developed. Unlike traditional methods, this technique involves mixing protein and precipitant directly on an electron microscopy...
6.
Gillman C, Nicolas W, Martynowycz M, Gonen T
bioRxiv
. 2023 Apr;
PMID: 37034794
We have developed a novel crystal growth method known as suspended drop crystallization. Unlike traditional methods, this technique involves mixing protein and precipitant directly on an electron microscopy grid without...
7.
Martynowycz M, Shiriaeva A, Clabbers M, Nicolas W, Weaver S, Hattne J, et al.
Nat Commun
. 2023 Feb;
14(1):1086.
PMID: 36841804
Crystallizing G protein-coupled receptors (GPCRs) in lipidic cubic phase (LCP) often yields crystals suited for the cryogenic electron microscopy (cryoEM) method microcrystal electron diffraction (MicroED). However, sample preparation is challenging....
8.
Nicolas W, Jensen G, Meyerowitz E
Bio Protoc
. 2022 Dec;
12(23).
PMID: 36561119
Cryo-electron tomography (cryo-ET) is a formidable technique to observe the inner workings of vitrified cells at a nanometric resolution in near-native conditions and in three-dimensions. One consequent drawback of this...
9.
Nicolas W, Fassler F, Dutka P, Schur F, Jensen G, Meyerowitz E
Curr Biol
. 2022 May;
32(11):2375-2389.e6.
PMID: 35508170
One hallmark of plant cells is their cell wall. They protect cells against the environment and high turgor and mediate morphogenesis through the dynamics of their mechanical and chemical properties....
10.
Kaplan M, Chreifi G, Metskas L, Liedtke J, Wood C, Oikonomou C, et al.
Elife
. 2021 Sep;
10.
PMID: 34468314
The ability to produce outer membrane projections in the form of tubular membrane extensions (MEs) and membrane vesicles (MVs) is a widespread phenomenon among diderm bacteria. Despite this, our knowledge...