William J Kowalski
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Explore the profile of William J Kowalski including associated specialties, affiliations and a list of published articles.
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18
Citations
275
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Recent Articles
1.
Kowalski W, Vatti S, Sakamoto T, Li W, Odutola S, Liu C, et al.
Sci Rep
. 2025 Feb;
15(1):7150.
PMID: 40021912
The dynamic remodeling of the nascent vascular network into a mature hierarchy is essential for embryo survival. Cell behaviors and signaling mechanisms are often investigated with animal models and perfused...
2.
Kowalski W, Garcia-Pak I, Li W, Uosaki H, Tampakakis E, Zou J, et al.
Front Cell Dev Biol
. 2022 Apr;
10:850645.
PMID: 35359438
Embryos devoid of autonomic innervation suffer sudden cardiac death. However, whether autonomic neurons have a role in heart development is poorly understood. To investigate if sympathetic neurons impact cardiomyocyte maturation,...
3.
Chronic Optogenetic Pacing of Human-Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues
Dwenger M, Kowalski W, Masumoto H, Nakane T, Keller B
Methods Mol Biol
. 2020 Sep;
2191:151-169.
PMID: 32865744
The delivery of cells into damaged myocardium induces limited cardiac regeneration due to extensive cell death. In an effort to limit cell death, our lab formulates three-dimensional matrices as a...
4.
Nakane T, Abulaiti M, Sasaki Y, Kowalski W, Keller B, Masumoto H
J Vis Exp
. 2020 Jun;
(160).
PMID: 32597877
The current protocol describes methods to generate scalable, mesh-shaped engineered cardiac tissues (ECTs) composed of cardiovascular cells derived from human induced pluripotent stem cells (hiPSCs), which are developed towards the...
5.
Keller B, Kowalski W, Tinney J, Tobita K, Hu N
J Cardiovasc Dev Dis
. 2020 Jun;
7(2).
PMID: 32545681
The goal of this review is to provide a broad overview of the biomechanical maturation and regulation of vertebrate cardiovascular (CV) morphogenesis and the evidence for mechanistic relationships between function...
6.
Dwenger M, Kowalski W, Ye F, Yuan F, Tinney J, Setozaki S, et al.
J Tissue Eng
. 2019 Apr;
10:2041731419841748.
PMID: 31024681
The immaturity of human induced pluripotent stem cell derived engineered cardiac tissues limits their ability to regenerate damaged myocardium and to serve as robust models for human disease and drug...
7.
Karakaya C, Goktas S, Celik M, Kowalski W, Keller B, Pekkan K
Sci Rep
. 2018 Nov;
8(1):16948.
PMID: 30446764
Embryonic aortic arches (AA) are initially bilaterally paired, transitional vessels and failures in remodeling based on hemodynamic and growth-related adaptations cause a spectrum of congenital heart disease (CHD) anatomies. Identifying...
8.
Kowalski W, Yuan F, Nakane T, Masumoto H, Dwenger M, Ye F, et al.
Microsc Microanal
. 2017 Jun;
23(4):826-842.
PMID: 28625174
Biological tissues have complex, three-dimensional (3D) organizations of cells and matrix factors that provide the architecture necessary to meet morphogenic and functional demands. Disordered cell alignment is associated with congenital...
9.
Nakane T, Masumoto H, Tinney J, Yuan F, Kowalski W, Ye F, et al.
Sci Rep
. 2017 Apr;
7:45641.
PMID: 28368043
The current study describes a scalable, porous large-format engineered cardiac tissue (LF-ECT) composed of human induced pluripotent stem cells (hiPSCs) derived multiple lineage cardiac cells with varied 3D geometries and...
10.
Goktas S, Uslu F, Kowalski W, Ermek E, Keller B, Pekkan K
PLoS One
. 2016 Aug;
11(8):e0161611.
PMID: 27552150
The role of hemodynamic forces within the embryo as biomechanical regulators for cardiovascular morphogenesis, growth, and remodeling is well supported through the experimental studies. Furthermore, clinical experience suggests that perturbed...