William E Hoffman
Overview
Explore the profile of William E Hoffman including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
181
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Recent Articles
1.
Helal C, Arnold E, Boyden T, Chang C, Chappie T, Fennell K, et al.
J Med Chem
. 2018 Apr;
61(8):3753.
PMID: 29624389
No abstract available.
2.
Helal C, Arnold E, Boyden T, Chang C, Chappie T, Fisher E, et al.
J Med Chem
. 2018 Jan;
61(3):1001-1018.
PMID: 29293004
Computational modeling was used to direct the synthesis of analogs of previously reported phosphodiesterase 2A (PDE2A) inhibitor 1 with an imidazotriazine core to yield compounds of significantly enhanced potency. The...
3.
Helal C, Arnold E, Boyden T, Chang C, Chappie T, Fennell K, et al.
J Med Chem
. 2017 Jun;
60(13):5673-5698.
PMID: 28574706
Phosphodiesterase 2A (PDE2A) inhibitors have been reported to demonstrate in vivo activity in preclinical models of cognition. To more fully explore the biology of PDE2A inhibition, we sought to identify...
4.
Claffey M, Helal C, Verhoest P, Kang Z, Fors K, Jung S, et al.
J Med Chem
. 2012 Oct;
55(21):9055-68.
PMID: 23025719
Phosphodiesterase 9A inhibitors have shown activity in preclinical models of cognition with potential application as novel therapies for treating Alzheimer's disease. Our clinical candidate, PF-04447943 (2), demonstrated acceptable CNS permeability...
5.
Gatto R, Hoffman W, Mueller M, Paisansathan C, Charbel F
J Biomed Opt
. 2008 Jan;
12(6):062113.
PMID: 18163816
Previous studies showed that the cerebrovasodilation response to hypercapnia is attenuated with aging. The purpose of this study was to determine if normal aging attenuates increases in brain oxygenation during...
6.
Paisansathan C, Lee M, Hoffman W, Wheeler P
Clin Auton Res
. 2007 Sep;
17(6):370-4.
PMID: 17767378
We evaluated cardiac vagal activity during sevoflurane anesthesia in neurosurgical patients. Heart rate variability was determined by power spectral analysis and entropy with the patient awake and during sevoflurane anesthesia....
7.
Paisansathan C, Hoffman W, Lee M, Ananda R, Wheeler P
J Clin Monit Comput
. 2007 Jul;
21(5):265-9.
PMID: 17641979
Objective: Although intracranial tumors may affect autonomic function, there are few reports of autonomic changes during anesthesia. The purpose of this study was to evaluate autonomic effects of anesthesia in...
8.
Feld J, Hoffman W, Paisansathan C, Park H, Ananda R
J Clin Anesth
. 2007 Feb;
19(1):30-6.
PMID: 17321924
Study Objective: To evaluate autonomic activity with dexmedetomidine or fentanyl infusion and desflurane anesthesia during laparoscopic gastric banding. Study Design: Randomized, single-blinded, open-label study. Setting: Operating rooms at a university...
9.
Feld J, Hoffman W
J Clin Monit Comput
. 2006 Jul;
20(4):229-34.
PMID: 16819583
Objective: There is a potential use for spectral entropy or bispectral index (BIS) for controlling level of anesthesia, but it is not known how these EEG monitors relate during steady...
10.
Feld J, Hoffman W, Stechert M, Hoffman I, Ananda R
J Clin Anesth
. 2006 Mar;
18(1):24-8.
PMID: 16517328
Study Objective: Because fentanyl has ventilatory depressing effects, alternative methods for analgesia may be beneficial for management of bariatric surgery. We evaluated whether dexmedetomidine infusion could replace fentanyl for facilitation...