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William Deraedt

Explore the profile of William Deraedt including associated specialties, affiliations and a list of published articles. Areas
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Articles 32
Citations 3183
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Recent Articles
1.
Dhakal B, He J, Schecter J, Deraedt W, Slaughter A, Lonardi C, et al.
Clin Lymphoma Myeloma Leuk . 2025 Feb; PMID: 39966019
Background: Early continuous lenalidomide use for multiple myeloma (MM) treatment has led to more patients with lenalidomide-refractory disease at earlier lines of therapy (LOTs). Real-world treatment practices and outcomes in...
2.
Harrison S, Touzeau C, Kint N, Li K, Nguyen T, Mayeur-Rousse C, et al.
N Engl J Med . 2025 Feb; 392(7):677-685. PMID: 39938094
We describe two patients in whom malignant monoclonal T-cell lymphoproliferation developed after administration of chimeric antigen receptor (CAR) T-cell therapy with ciltacabtagene autoleucel (cilta-cel) in the phase 3 CARTITUDE-4 trial....
3.
Mina R, Mylin A, Yokoyama H, Magen H, Alsdorf W, Minnema M, et al.
Lancet Haematol . 2025 Jan; 12(1):e45-e56. PMID: 39756844
Background: In CARTITUDE-4, ciltacabtagene autoleucel (cilta-cel) significantly improved progression-free survival (primary endpoint; previously reported) versus standard of care in patients with relapsed, lenalidomide-refractory multiple myeloma. We report here patient-reported outcomes....
4.
Yong K, Einsele H, Schecter J, Roccia T, Deraedt W, Lendvai N, et al.
Eur J Cancer . 2024 Dec; 215:115157. PMID: 39673835
Background: The introduction of proteasome inhibitors (PIs) and lenalidomide as treatment for newly diagnosed multiple myeloma (MM) has led to an increased population of lenalidomide-refractory patients. Limited data are available...
5.
Dhakal B, Einsele H, Schecter J, Deraedt W, Lendvai N, Slaughter A, et al.
Blood Adv . 2024 Aug; 8(19):5062-5071. PMID: 39110988
In the context of multiple myeloma (MM), early use of the immunomodulatory drug lenalidomide has led to an increased population of patients with lenalidomide-refractory MM in early-line settings, but their...
6.
Htut M, Dhakal B, Cohen A, Martin T, Berdeja J, Usmani S, et al.
Clin Lymphoma Myeloma Leuk . 2023 Sep; 23(12):882-888. PMID: 37716872
Background: Patients with prior allogeneic stem cell transplant (alloSCT) are typically excluded from trials of chimeric antigen receptor (CAR) T cell therapies, because their engineered cells may include allogeneic T...
7.
Delforge M, Vekemans M, Depaus J, Meuleman N, Velde A, Vande Broek I, et al.
Hemasphere . 2022 Dec; 6(12):e813. PMID: 36479545
No abstract available.
8.
Cohen A, Hari P, Htut M, Berdeja J, Usmani S, Madduri D, et al.
Clin Lymphoma Myeloma Leuk . 2022 Nov; 23(1):68-77. PMID: 36357295
Introduction: Ciltacabtagene autoleucel (cilta-cel), a novel chimeric antigen receptor T (CAR-T) cell therapy, has demonstrated early, deep, and durable clinical responses in heavily pretreated patients with relapsed/refractory multiple myeloma (RRMM),...
9.
Martin T, Usmani S, Schecter J, Roccia T, Jackson C, Deraedt W, et al.
Curr Med Res Opin . 2022 Oct; 39(1):81-89. PMID: 36271807
Objective: This study used the latest available data cuts from the CARTITUDE-1 and KarMMa clinical trials to update previously published matching-adjusted indirect treatment comparisons (MAICs) assessing the comparative efficacy of...
10.
Martin T, Lin Y, Agha M, Cohen A, Htut M, Stewart A, et al.
Lancet Haematol . 2022 Oct; 9(12):e897-e905. PMID: 36215989
Background: CARTITUDE-1 is a phase 1b-2 study evaluating ciltacabtagene autoleucel (cilta-cel), a chimeric antigen receptor T cell therapy with two B-cell maturation antigen-targeting single-domain antibodies, in patients with relapsed or...