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William D Tolbert

Explore the profile of William D Tolbert including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 59
Citations 1033
Followers 0
Related Specialties
Microbiology
Allergy & Immunology
Cell Biology
Top 10 Co-Authors
Marzena Pazgier
Andres Finzi
Jonathan Richard
Shilei Ding
Jeremie Prevost
Halima Medjahed
Amos B Smith 3rd
Rebekah Sherburn
Neelakshi Gohain
Suneetha Gottumukkala
Published In
J Virol
bioRxiv
mBio
Front Immunol
medRxiv
Affiliations
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Recent Articles
1.
CD4 T cell counts are inversely correlated with anti-cluster A antibodies in antiretroviral therapy-treated PLWH
Benlarbi M, Richard J, Clemente T, Bourassa C, Tolbert W, Gottumukkala S, et al.
medRxiv . 2025 Mar; PMID: 40061344
While antiretroviral therapy efficiently suppresses viral replication, inflammation and immune dysfunction persist in some people living with HIV-1 (PLWH). Soluble gp120 (sgp120) has been detected in PLWH plasma and its...
2.
Optimization of a Piperidine CD4-Mimetic Scaffold Sensitizing HIV-1 Infected Cells to Antibody-Dependent Cellular Cytotoxicity
Lee D, Niu L, Ding S, Zhu H, Tolbert W, Medjahed H, et al.
ACS Med Chem Lett . 2024 Nov; 15(11):1961-1969. PMID: 39563795
The ability of the HIV-1 accessory proteins Nef and Vpu to decrease CD4 protects infected cells from antibody-dependent cellular cytotoxicity (ADCC) by limiting the exposure of vulnerable epitopes to envelope...
3.
The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC
Richard J, Grunst M, Niu L, Diaz-Salinas M, Tolbert W, Marchitto L, et al.
bioRxiv . 2024 Sep; PMID: 39253431
HIV-1 envelope glycoproteins (Env) from primary HIV-1 isolates typically adopt a pretriggered "closed" conformation that resists to CD4-induced (CD4i) non-neutralizing antibodies (nnAbs) mediating antibody-dependent cellular cytotoxicity (ADCC). CD4-mimetic compounds (CD4mcs)...
4.
The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity
Marchitto L, Richard J, Prevost J, Tauzin A, Yang D, Chiu T, et al.
J Virol . 2024 Sep; 98(10):e0101624. PMID: 39248460
The majority of naturally elicited antibodies against the HIV-1 envelope glycoproteins (Env) are non-neutralizing (nnAbs) because they are unable to recognize the Env trimer in its native "closed" conformation. Nevertheless,...
5.
Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in the presence of CD4-mimetics
Tauzin A, Marchitto L, Belanger E, Benlarbi M, Beaudoin-Bussieres G, Prevost J, et al.
J Virol . 2024 Sep; 98(10):e0096024. PMID: 39230306
Importance: There are several reasons that make it difficult to target the HIV reservoir. One of them is the capacity of infected cells to prevent the recognition of HIV-1 envelope...
6.
The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity
Marchitto L, Richard J, Prevost J, Tauzin A, Yang D, Chiu T, et al.
bioRxiv . 2024 Jun; PMID: 38895270
The majority of naturally-elicited antibodies against the HIV-1 envelope glycoproteins (Env) are non-neutralizing (nnAbs), because they are unable to recognize the Env timer in its native "closed" conformation. Nevertheless, it...
7.
Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in presence of CD4-mimetics
Tauzin A, Marchitto L, Belanger E, Benlarbi M, Beaudoin-Bussieres G, Prevost J, et al.
medRxiv . 2024 Jun; PMID: 38883797
CD4-mimetics (CD4mcs) are small molecule compounds that mimic the interaction of the CD4 receptor with HIV-1 envelope glycoproteins (Env). Env from primary viruses normally samples a "closed" conformation which occludes...
8.
Defining genetic diversity of rhesus macaque Fcγ receptors with long-read RNA sequencing
Conley H, He M, Easterhoff D, Kirshner H, Cocklin S, Meyer J, et al.
Front Immunol . 2024 Jan; 14:1306292. PMID: 38264644
Fcγ receptors (FcγRs) are membrane-bound glycoproteins that bind to the fragment crystallizable (Fc) constant regions of IgG antibodies. Interactions between IgG immune complexes and FcγRs can initiate signal transduction that...
9.
Plasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy-Treated Individuals With Undetectable Viremia
Benlarbi M, Richard J, Bourassa C, Tolbert W, Chartrand-Lefebvre C, Gendron-Lepage G, et al.
J Infect Dis . 2023 Nov; 229(3):763-774. PMID: 38035854
Background: Chronic inflammation persists in some people living with human immunodeficiency virus (HIV) during antiretroviral therapy and is associated with premature aging. The glycoprotein 120 (gp120) subunit of HIV-1 envelope...
10.
Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir
Prevost J, Chen Y, Zhou F, Tolbert W, Gasser R, Medjahed H, et al.
Nat Commun . 2023 Oct; 14(1):6710. PMID: 37872202
The HIV-1 entry inhibitor temsavir prevents the viral receptor CD4 (cluster of differentiation 4) from interacting with the envelope glycoprotein (Env) and blocks its conformational changes. To do this, temsavir...