William C Drewe
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Explore the profile of William C Drewe including associated specialties, affiliations and a list of published articles.
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10
Citations
49
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Recent Articles
1.
Chetty S, Armstrong T, Sharma Kharkwal S, Drewe W, De Matteis C, Evangelopoulos D, et al.
Pharmaceuticals (Basel)
. 2021 Apr;
14(4).
PMID: 33919737
The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) has reinforced the need for the development of new anti-TB drugs. The first line drug isoniazid inhibits InhA. This...
2.
Pognan F, Steger-Hartmann T, Diaz C, Blomberg N, Bringezu F, Briggs K, et al.
Pharmaceuticals (Basel)
. 2021 Apr;
14(3).
PMID: 33800393
eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety assessment...
3.
Briggs K, Bosc N, Camara T, Diaz C, Drew P, Drewe W, et al.
ALTEX
. 2021 Feb;
38(2):187-197.
PMID: 33637997
Pre-competitive data sharing can offer the pharmaceutical industry significant benefits in terms of reducing the time and costs involved in getting a new drug to market through more informed testing...
4.
Drewe W, Dobo K, Sobol Z, Bercu J, Parris P, Nicolette J
Int J Toxicol
. 2021 Feb;
40(3):285-298.
PMID: 33525949
A workshop entitled "Deriving Compound-Specific Exposure Limits for Chemicals Used in Pharmaceutical Synthesis" was held at the 2018 Genetic Toxicology Association annual meeting. The objectives of the workshop were to...
5.
Tennant R, Guesne S, Canipa S, Cayley A, Drewe W, Honma M, et al.
Mutagenesis
. 2018 Oct;
34(1):111-121.
PMID: 30281100
As part of the hazard and risk assessment of chemicals in man, it is important to assess the ability of a chemical to induce mutations in vivo. Because of the...
6.
Drewe W, Payne M, Williams R
Contact Dermatitis
. 2017 Apr;
76(5):312-314.
PMID: 28386969
No abstract available.
7.
Canipa S, Cayley A, Drewe W, Williams R, Hamada S, Hirose A, et al.
Mutagenesis
. 2015 Jul;
31(1):17-25.
PMID: 26142242
While the in vivo genotoxicity of a compound may not always correlate well with its activity in in vitro test systems, for certain compound classes a good overlap may exist...
8.
Roth S, Drewe W, Thomas N
Nat Protoc
. 2010 Dec;
5(12):1967-73.
PMID: 21127494
A concise and highly efficient synthetic route to L-azidohomoalanine (L-Aha) and its homologues is presented here. These chemically modified amino acids are used for the introduction of bioorthogonal handles into...
9.
Drewe W, Nanjunda R, Gunaratnam M, Beltran M, Parkinson G, Reszka A, et al.
J Med Chem
. 2008 Dec;
51(24):7751-67.
PMID: 19053833
The design and synthesis of a series of urea-based nonpolycyclic aromatic ligands with alkylaminoanilino side chains as telomeric and genomic G-quadruplex DNA interacting agents are described. Their interactions with quadruplexes...
10.
Drewe W, Neidle S
Chem Commun (Camb)
. 2008 Nov;
(42):5295-7.
PMID: 18985188
A series of diarylurea ligands were designed to interact selectively with G-quadruplexes and were synthesised using copper(I) catalysed 'click' chemistry to incorporate the 1,4-substituted 1,2,3-triazole ring into the core of...