Willem-Jan Krebber
Overview
Explore the profile of Willem-Jan Krebber including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
1190
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Recent Articles
1.
Jansen D, de Beijer M, Luijten R, Kwappenberg K, Wiekmeijer A, Kessler A, et al.
Front Immunol
. 2023 Oct;
14:1163118.
PMID: 37781393
Introduction: Therapeutic vaccination based on synthetic long peptides (SLP) containing both CD4+ and CD8+ T cell epitopes is a promising treatment strategy for chronic hepatitis B infection (cHBV). Methods: We...
2.
Stegmann T, Wiekmeijer A, Kwappenberg K, van Duikeren S, Bhoelan F, Bemelman D, et al.
Cancer Immunol Immunother
. 2023 May;
72(8):2851-2864.
PMID: 37222770
Therapeutic cancer vaccines trigger CD4 + and CD8 + T cell responses capable of established tumor eradication. Current platforms include DNA, mRNA and synthetic long peptide (SLP) vaccines, all aiming...
3.
Speetjens F, Welters M, Slingerland M, van Poelgeest M, de Vos van Steenwijk P, Roozen I, et al.
J Immunother Cancer
. 2022 Oct;
10(10).
PMID: 36261215
Background: Amplivant is a molecularly optimized Toll-like receptor 2 ligand that can be covalently conjugated to tumor peptide antigens. In preclinical models, amplivant-adjuvanted synthetic long peptides (SLPs) strongly enhanced antigen...
4.
Brentville V, Metheringham R, Daniels I, Atabani S, Symonds P, Cook K, et al.
J Immunother Cancer
. 2020 Jun;
8(1).
PMID: 32561639
Background: Stress-induced post-translational modifications occur during autophagy and can result in generation of new epitopes and immune recognition. One such modification is the conversion of arginine to citrulline by peptidylarginine...
5.
Dou Y, Jansen D, van den Bosch A, de Man R, van Montfoort N, Araman C, et al.
Antiviral Res
. 2020 Feb;
178:104746.
PMID: 32081741
Synthetic long peptide (SLP) vaccination is a promising new treatment strategy for patients with a chronic hepatitis B virus (HBV) infection. We have previously shown that a prototype HBV-core protein...
6.
Dou Y, van Montfoort N, van den Bosch A, de Man R, Zom G, Krebber W, et al.
J Infect Dis
. 2017 Dec;
217(5):827-839.
PMID: 29220492
Background: Vaccination with synthetic long peptides (SLP) is a promising new treatment strategy for chronic hepatitis B virus (CHB). SLP can induce broad T-cell responses for all HLA types. Here...
7.
Gubin M, Zhang X, Schuster H, Caron E, Ward J, Noguchi T, et al.
Nature
. 2014 Nov;
515(7528):577-81.
PMID: 25428507
The immune system influences the fate of developing cancers by not only functioning as a tumour promoter that facilitates cellular transformation, promotes tumour growth and sculpts tumour cell immunogenicity, but...
8.
van Duikeren S, Fransen M, Redeker A, Wieles B, Platenburg G, Krebber W, et al.
J Immunol
. 2012 Aug;
189(7):3397-403.
PMID: 22914049
CD8(+) T cells have the potential to attack and eradicate cancer cells. The efficacy of therapeutic vaccines against cancer, however, lacks defined immune correlates of tumor eradication after (therapeutic) vaccination...