Wensheng Wei
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Explore the profile of Wensheng Wei including associated specialties, affiliations and a list of published articles.
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71
Citations
2159
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Recent Articles
1.
Zhang X, Zhang X, Ren J, Li J, Wei X, Yu Y, et al.
Nature
. 2025 Jan;
PMID: 39843744
The development of animal models is crucial for studying and treating mitochondrial diseases. Here we optimized adenine and cytosine deaminases to reduce off-target effects on the transcriptome and the mitochondrial...
2.
Qin S, Zhang X, Zhang Y, Miao D, Wei W, Bai Y
Chem Sci
. 2025 Jan;
16(7):3187-3197.
PMID: 39840293
Single-cell multi-dimensional analysis enables more profound biological insight, providing a comprehensive understanding of cell physiological processes. Due to limited cellular contents, the lack of protein and metabolite amplification ability, and...
3.
Li R, Lian Z, Wei W
Polymers (Basel)
. 2025 Jan;
16(24.
PMID: 39771425
Rubber is widely used in situations involving cyclic loads, and the influence of temperature on rubber properties is particularly pronounced under cyclic loading. In this study, mechanical property tests and...
4.
Pan Q, Zhang Z, Xiong Y, Bao Y, Chen T, Xu P, et al.
Cell Rep
. 2024 Dec;
43(12):115047.
PMID: 39661519
Maintaining genomic stability is vital for cellular equilibrium. In this study, we combined CRISPR-mediated base editing with pooled screening technologies to identify numerous mutations in lysine residues and protein-coding genes....
5.
He X, Liu Y, Gao X, Tang F, Tian Y, Gong S, et al.
J Immunother Cancer
. 2024 Nov;
12(11).
PMID: 39615895
Background: Programmed death-1 (PD-1) checkpoint blockade has revolutionized cancer therapy, yet its clinical success is confined to a subset of patients, underscoring the urgent need to understand the molecular underpinnings...
6.
Bao Y, Wei W
STAR Protoc
. 2024 Oct;
5(4):103418.
PMID: 39471176
Amino acid residues are crucial to protein structure and function and have links to various human diseases. Here, we present a protocol for screening functional lysine residues across the human...
7.
Li Y, Xu T, Ma H, Yue D, Lamao Q, Liu Y, et al.
Nat Chem Biol
. 2024 Sep;
PMID: 39313591
Systematic perturbation of amino acids at endogenous loci provides diverse insights into protein function. Here, we performed a genome-wide screen to globally assess the cell fitness dependency of serine, threonine...
8.
Zhang X, Yi Z, Tang W, Wei W
Biophys Rep
. 2024 Sep;
10(4):191-200.
PMID: 39281197
Mitochondrial base editing tools hold great promise for the investigation and treatment of mitochondrial diseases. Mitochondrial DNA base editors (mitoBEs) integrate a programmable transcription-activator-like effector (TALE) protein with single-stranded DNA...
9.
Yi Z, Zhang X, Wei X, Li J, Ren J, Zhang X, et al.
Nat Commun
. 2024 Jul;
15(1):6397.
PMID: 39080265
DNA base editing technologies predominantly utilize engineered deaminases, limiting their ability to edit thymine and guanine directly. In this study, we successfully achieve base editing of both cytidine and thymine...
10.
Wu Z, Lamao Q, Gu M, Jin X, Liu Y, Tian F, et al.
Cell Mol Immunol
. 2024 Feb;
21(4):362-373.
PMID: 38374404
Vγ9Vδ2 T cells are specialized effector cells that have gained prominence as immunotherapy agents due to their ability to target and kill cells with altered pyrophosphate metabolites. In our effort...