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Wen-Hann Tan

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Articles 85
Citations 1590
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Recent Articles
11.
Tjeertes J, Bacino C, Bichell T, Bird L, Bustamante M, Crean R, et al.
J Neurodev Disord . 2023 Jul; 15(1):22. PMID: 37495977
Background: Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by the absence of a functional UBE3A gene, which causes developmental, behavioral, and medical challenges. While currently untreatable, comprehensive data...
12.
Khan N, Cabo R, Burdine R, Tan W, Keary C, Ochoa-Lubinoff C, et al.
Qual Life Res . 2023 Apr; 32(7):2059-2067. PMID: 37039911
Purpose: The primary goal of this analysis is to describe the health-related quality of life (HRQoL), medical history, and medication use among adolescents and adults individuals with Angelman syndrome (AS)....
13.
Yahalom C, Woods R, Akula J, Tan W, Fulton A
Ophthalmic Genet . 2023 Apr; 44(6):585-590. PMID: 37038737
Background: Microcephaly and chorioretinopathy (MCCRP) is a rare autosomal recessive (AR) disorder characterized by microcephaly, developmental delay, chorioretinopathy, and visual impairment. We characterized the long-term phenotype of an additional patient...
14.
Russell B, Kianmahd R, Munster C, Yu A, Ahad L, Tan W
Am J Med Genet A . 2023 Feb; 191(4):1050-1058. PMID: 36751885
Bohring-Opitz syndrome (BOS) is a rare genetic condition caused by pathogenic variants in ASXL1, which is a gene involved in chromatin regulation. BOS is characterized by severe intellectual disabilities, distinctive...
15.
Awamleh Z, Chater-Diehl E, Choufani S, Wei E, Kianmahd R, Yu A, et al.
Eur J Hum Genet . 2022 Apr; 30(6):695-702. PMID: 35361921
The additional sex combs-like (ASXL) gene family-encoded by ASXL1, ASXL2, and ASXL3-is crucial for mammalian development. Pathogenic variants in the ASXL gene family are associated with three phenotypically distinct neurodevelopmental...
16.
Baker E, Merton C, Tan W, Dudding-Byth T, Godler D, Sadhwani A
Eur J Med Genet . 2022 Feb; 65(4):104456. PMID: 35218942
Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by loss of expression of the maternally-inherited UBE3A on chromosome 15q11.2. In AS due to a chromosomal deletion that encompasses UBE3A,...
17.
Grebe S, Limon D, McNeel M, Guzick A, Peters S, Tan W, et al.
Am J Intellect Dev Disabil . 2022 Jan; 127(1):1-10. PMID: 34979033
Angelman Syndrome (AS) is a neurodevelopmental disorder most commonly caused by the impaired expression of the maternal UBE3A gene on chromosome 15. Though anxiety has been identified as a frequently...
18.
Hipp J, Frohlich J, Keute M, Tan W, Bird L
Biol Psychiatry Glob Open Sci . 2021 Nov; 1(3):201-209. PMID: 34841387
Background: Angelman syndrome (AS) is a rare neurodevelopmental disorder caused by the absence of functional UBE3A in neurons. Excess low-frequency oscillations as measured with electroencephalography (EEG) have been identified as...
19.
Gold N, Campbell I, Sheppard S, Tan W
Sci Rep . 2021 Oct; 11(1):19791. PMID: 34611197
Nevoid basal cell carcinoma syndrome (NBCCS) is a tumor predisposition condition, the cardinal features of which emerge in adolescence or adulthood. Using statistical optimization, this study proposes NBCCS criteria with...
20.
Cassater D, Bustamante M, Sach-Peltason L, Rotenberg A, Nespeca M, Tan W, et al.
Pediatr Neurol . 2021 Sep; 124:42-50. PMID: 34536900
Background: Epilepsy is highly prevalent in children with Angelman syndrome (AS), and its detailed characterization and relationship to the genotype (deletion vs nondeletion) is important both for medical practice and...