Weixi Gu
Overview
Explore the profile of Weixi Gu including associated specialties, affiliations and a list of published articles.
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14
Citations
480
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Recent Articles
1.
Manik M, Pan M, Xiao L, Gu W, Kim H, Pospich S, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(2):e2418988122.
PMID: 39786929
Innate immunity relies on Toll-like receptors (TLRs) to detect pathogen-associated molecular patterns. The TIR (Toll/interleukin-1 receptor) domain-containing TLR adaptors TRIF (TIR domain-containing adaptor-inducing interferon-β) and TRAM (TRIF-related adaptor molecule) are...
2.
Bhatt A, Mishra B, Gu W, Sorbello M, Xu H, Ve T, et al.
IUCrJ
. 2024 Aug;
11(Pt 5):695-707.
PMID: 39190506
The TIR (Toll/interleukin-1 receptor) domain represents a vital structural element shared by proteins with roles in immunity signalling pathways across phyla (from humans and plants to bacteria). Decades of research...
3.
Shi Y, Masic V, Mosaiab T, Rajaratman P, Hartley-Tassell L, Sorbello M, et al.
Sci Adv
. 2024 Jun;
10(26):eadn3310.
PMID: 38924412
Thoeris defense systems protect bacteria from infection by phages via abortive infection. In these systems, ThsB proteins serve as sensors of infection and generate signaling nucleotides that activate ThsA effectors....
4.
McGuinness H, Gu W, Shi Y, Kobe B, Ve T
Neuroscientist
. 2023 Apr;
30(4):473-492.
PMID: 37002660
Axons are an essential component of the nervous system, and axon degeneration is an early feature of many neurodegenerative disorders. The NAD metabolome plays an essential role in regulating axonal...
5.
Manik M, Shi Y, Li S, Zaydman M, Damaraju N, Eastman S, et al.
Science
. 2022 Sep;
377(6614):eadc8969.
PMID: 36048923
Cyclic adenosine diphosphate (ADP)-ribose (cADPR) isomers are signaling molecules produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via nicotinamide adenine dinucleotide (oxidized form) (NAD) hydrolysis. We show that v-cADPR...
6.
Shi Y, Kerry P, Nanson J, Bosanac T, Sasaki Y, Krauss R, et al.
Mol Cell
. 2022 Mar;
82(9):1643-1659.e10.
PMID: 35334231
The NADase SARM1 (sterile alpha and TIR motif containing 1) is a key executioner of axon degeneration and a therapeutic target for several neurodegenerative conditions. We show that a potent...
7.
Nimma S, Gu W, Manik M, Ve T, Nanson J, Kobe B
FEBS Lett
. 2022 Jan;
596(7):886-897.
PMID: 35038778
The Toll/interleukin-1 receptor (TIR) domains are key innate immune signalling modules. Here, we present the crystal structure of the TIR domain of human interleukin-1 receptor 10 (IL-1R10), also called interleukin...
8.
Loreto A, Angeletti C, Gu W, Osborne A, Nieuwenhuis B, Gilley J, et al.
Elife
. 2021 Dec;
10.
PMID: 34870595
Axon loss underlies symptom onset and progression in many neurodegenerative disorders. Axon degeneration in injury and disease is promoted by activation of the NAD-consuming enzyme SARM1. Here, we report a...
9.
Nimma S, Gu W, Maruta N, Li Y, Pan M, Saikot F, et al.
Front Immunol
. 2021 Dec;
12:784484.
PMID: 34868065
TIR (Toll/interleukin-1 receptor/resistance protein) domains are cytoplasmic domains widely found in animals and plants, where they are essential components of the innate immune system. A key feature of TIR-domain function...
10.
Gu W, Luo Z, Vonrhein C, Jia X, Ve T, Nanson J, et al.
Acta Crystallogr F Struct Biol Commun
. 2021 Oct;
77(Pt 10):364-373.
PMID: 34605441
The crystal structure determination of the armadillo repeat motif (ARM) domain of Drosophila SARM1 (dSARM1) is described, which required the combination of a number of sources of phase information in...