Wayne G Shreffler
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Explore the profile of Wayne G Shreffler including associated specialties, affiliations and a list of published articles.
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103
Citations
3049
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Recent Articles
1.
Sanchez-Martinez E, Rondeau L, Garrido-Romero M, da Luz B, Haas D, Yuen G, et al.
bioRxiv
. 2025 Mar;
PMID: 40027733
Anaphylaxis is an acute, potentially life-threatening reaction, often triggered by foods and largely mediated by IgE. A critically important aspect of anaphylaxis pertains to the factors that modulate its severity....
2.
Pongracic J, Gagnon R, Sussman G, Siri D, Oriel R, Brown-Whitehorn T, et al.
J Allergy Clin Immunol Pract
. 2025 Mar;
PMID: 40023371
Background: Due to limited treatment options for peanut allergy, patients remain at risk for allergic reactions due to accidental exposure. Epicutaneous immunotherapy (EPIT) is a novel treatment being investigated for...
3.
Flom J, Shreffler W, Perrett K
J Allergy Clin Immunol Pract
. 2025 Feb;
PMID: 40010566
Management of IgE-mediated food allergy is shifting from reactive management strategies (allergen avoidance and ready access to autoinjectable epinephrine in case of exposure) to proactive therapies. These therapies are in...
4.
Dilollo J, Hu A, Qu H, Canziani K, Clement R, McCright S, et al.
J Allergy Clin Immunol
. 2025 Feb;
PMID: 39891629
No abstract available.
5.
Lal M, Burk C, Gautam R, Mrozek Z, Canziani K, Trachsel T, et al.
Cell Mol Gastroenterol Hepatol
. 2025 Jan;
:101466.
PMID: 39884574
Background & Aims: Eosinophilic esophagitis (EoE) is a chronic esophageal inflammatory disorder characterized by eosinophil-rich mucosal inflammation and tissue remodeling. Prior research has revealed the upregulation of interferon (IFN) response...
6.
Chinthrajah R, Sindher S, Nadeau K, Leflein J, Spergel J, Petroni D, et al.
Allergy
. 2024 Dec;
80(3):827-842.
PMID: 39673367
Background: Peanut allergy is a common, life-threatening food allergy in children. We evaluated whether dupilumab, which blocks the activity of interleukin (IL)-4/IL-13, enhances the efficacy of oral immunotherapy (OIT) AR101...
7.
Marget M, Baker C, OConnell I, Shreffler W, Yuan Q, Martin V
J Pediatr Gastroenterol Nutr
. 2024 Nov;
80(1):108-112.
PMID: 39584247
We sought to prospectively evaluate whether food protein-induced allergic proctocolitis (FPIAP) during infancy is associated with increased constipation later in childhood. Using the Gastrointestinal Microbiome and Allergic Proctocolitis (GMAP) cohort,...
8.
Virkud Y, Styles J, Kelly R, Patil S, Ruiter B, Smith N, et al.
Pediatr Allergy Immunol
. 2024 Nov;
35(11):e14267.
PMID: 39530396
Background: The immunometabolic mechanisms underlying variable responses to oral immunotherapy (OIT) in patients with IgE-mediated food allergy are unknown. Objective: To identify novel pathways associated with tolerance in food allergy,...
9.
Vickery B, Bird J, Chinthrajah R, Jones S, Keet C, Kim E, et al.
J Allergy Clin Immunol Pract
. 2024 Sep;
12(11):2947-2954.
PMID: 39293782
In February 2024, omalizumab was approved by the U.S. Food and Drug Administration for the treatment of food allergy, based on data from the landmark phase 3 clinical trial, Omalizumab...
10.
Shreffler W
J Food Allergy
. 2024 Jul;
2(1):7-10.
PMID: 39022160
The pathophysiology of immunoglobulin E (IgE) mediated food allergy has been understood on a superficial level for several decades. Surveillance by dendritic cells for exogenous antigens leads to a high-affinity...