Wataru Koguchi
Overview
Explore the profile of Wataru Koguchi including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
78
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Recent Articles
1.
Takeshima H, Kobayashi N, Koguchi W, Ishikawa M, Sugiyama F, Ishimitsu T
J Atheroscler Thromb
. 2011 Dec;
19(4):326-36.
PMID: 22166971
Aim: Rho-kinase plays a critical role in various cellular functions. p38 mitogen-activated protein kinase (p38 MAPK) plays a central role in the inflammatory cytokine response to immune challenge. We evaluated...
2.
Koguchi W, Kobayashi N, Takeshima H, Ishikawa M, Sugiyama F, Ishimitsu T
Circ J
. 2011 Nov;
76(1):137-44.
PMID: 22082814
Background: Apelin and its cognate G protein-coupled receptor, APJ, constitute a signaling pathway with a positive inotropic effect on cardiac function. Recently, we and other investigators demonstrated that a reduction...
3.
Kobayashi N, Fukushima H, Takeshima H, Koguchi W, Mamada Y, Hirata H, et al.
Am J Hypertens
. 2010 May;
23(9):1007-13.
PMID: 20431528
Background: We have demonstrated that angiotensin II receptor blocker (ARB) improved endothelial progenitor cells (EPCs) dysfunction through the antioxidative mechanism. Therefore, we investigate whether the selective mineralocorticoid receptor (MR) antagonist...
4.
Fukushima H, Kobayashi N, Takeshima H, Koguchi W, Ishimitsu T
J Cardiovasc Pharmacol
. 2009 Nov;
55(1):83-8.
PMID: 19904215
Apelin and its cognate G protein-coupled receptor APJ constitute a signaling pathway with a positive inotropic effect on cardiac function, and the apelin/APJ pathway seems to have opposing physiological role...
5.
Cardioprotective effects of pitavastatin on cardiac performance and remodeling in failing rat hearts
Kobayashi N, Takeshima H, Fukushima H, Koguchi W, Mamada Y, Hirata H, et al.
Am J Hypertens
. 2008 Nov;
22(2):176-82.
PMID: 19039310
Background: Activation of phosphatidylinositol 3-kinase (PI3K)-Akt signaling by statins increases the activity of endothelial nitric oxide synthase (eNOS). We investigate whether statins (pitavastatin) improve cardiac function and remodeling via eNOS...