Wai Hei Lam
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Explore the profile of Wai Hei Lam including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
171
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Recent Articles
1.
Luo J, Lam W, Yu D, Chao V, Zopfi M, Khoo C, et al.
Nat Struct Mol Biol
. 2024 Nov;
32(2):358-368.
PMID: 39496813
Acetylation at α-tubulin K40 is the sole post-translational modification preferred to occur inside the lumen of hollow cylindrical microtubules. However, how tubulin acetyltransferases access the luminal K40 in micrometer-long microtubules...
2.
Wu Y, Zhang Q, Lin Y, Lam W, Zhai Y
Nat Commun
. 2024 Sep;
15(1):8039.
PMID: 39271725
In eukaryotes, the origin recognition complex (ORC) faciliates the assembly of pre-replicative complex (pre-RC) at origin DNA for replication licensing. Here we show that the N-terminal intrinsically disordered region (IDR)...
3.
Zhang Q, Lam W, Zhai Y
Curr Opin Struct Biol
. 2024 Jul;
88:102876.
PMID: 38986167
To initiate DNA replication, it is essential to properly assemble a pair of replicative helicases at each replication origin. While the general principle of this process applies universally from prokaryotes...
4.
Xu Z, Feng J, Yu D, Huo Y, Ma X, Lam W, et al.
Nat Commun
. 2023 Sep;
14(1):5849.
PMID: 37730685
The replisome that replicates the eukaryotic genome consists of at least three engines: the Cdc45-MCM-GINS (CMG) helicase that separates duplex DNA at the replication fork and two DNA polymerases, one...
5.
Lin J, Wu Y, Tian G, Yu D, Yang E, Lam W, et al.
Science
. 2023 Feb;
379(6633):717-723.
PMID: 36795828
Methylation of histone H3 lysine-79 (H3K79) is an epigenetic mark for gene regulation in development, cellular differentiation, and disease progression. However, how this histone mark is translated into downstream effects...
6.
Li J, Dong J, Wang W, Yu D, Fan X, Hui Y, et al.
Cell
. 2023 Jan;
186(1):98-111.e21.
PMID: 36608662
In eukaryotes, DNA replication initiation requires assembly and activation of the minichromosome maintenance (MCM) 2-7 double hexamer (DH) to melt origin DNA strands. However, the mechanism for this initial melting...
7.
Lee C, Cheung M, Li J, Zhao Y, Lam W, Ho V, et al.
Nat Commun
. 2021 Jan;
12(1):33.
PMID: 33397927
The Origin Recognition Complex (ORC) is an evolutionarily conserved six-subunit protein complex that binds specific sites at many locations to coordinately replicate the entire eukaryote genome. Though highly conserved in...
8.
Li N, Lam W, Zhai Y, Cheng J, Cheng E, Zhao Y, et al.
Nature
. 2018 Jul;
559(7713):217-222.
PMID: 29973722
The six-subunit origin recognition complex (ORC) binds to DNA to mark the site for the initiation of replication in eukaryotes. Here we report a 3 Å cryo-electron microscopy structure of...
9.
Woo P, Lau S, Lau C, Tung E, Chong K, Yang F, et al.
PLoS Negl Trop Dis
. 2016 Aug;
10(8):e0004907.
PMID: 27560160
Background: Talaromyces marneffei is an opportunistic dimorphic fungus prevalent in Southeast Asia. We previously demonstrated that Mp1p is an immunogenic surface and secretory mannoprotein of T. marneffei. Since Mp1p is...