W W Newcomb
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Explore the profile of W W Newcomb including associated specialties, affiliations and a list of published articles.
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55
Citations
2536
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Recent Articles
1.
Newcomb W, Juhas R, Thomsen D, Homa F, BURCH A, Weller S, et al.
J Virol
. 2001 Oct;
75(22):10923-32.
PMID: 11602732
During replication of herpes simplex virus type 1 (HSV-1), viral DNA is synthesized in the infected cell nucleus, where DNA-free capsids are also assembled. Genome-length DNA molecules are then cut...
2.
Newcomb W, Homa F, Thomsen D, Brown J
J Struct Biol
. 2001 May;
133(1):23-31.
PMID: 11356061
The herpes simplex virus 1 capsid is formed in the infected cell nucleus by way of a spherical, less robust intermediate called the procapsid. Procapsid assembly requires the capsid shell...
3.
Trus B, Heymann J, Nealon K, Cheng N, Newcomb W, Brown J, et al.
J Virol
. 2001 Feb;
75(6):2879-90.
PMID: 11222713
The capsid of Kaposi's sarcoma-associated herpesvirus (KSHV) was visualized at 24-A resolution by cryoelectron microscopy. Despite limited sequence similarity between corresponding capsid proteins, KSHV has the same T=16 triangulation number...
4.
Nealon K, Newcomb W, Pray T, Craik C, Brown J, Kedes D
J Virol
. 2001 Feb;
75(6):2866-78.
PMID: 11222712
Despite the discovery of Epstein-Barr virus more than 35 years ago, a thorough understanding of gammaherpesvirus capsid composition and structure has remained elusive. We approached this problem by purifying capsids...
5.
Sheaffer A, Newcomb W, Gao M, Yu D, Weller S, Brown J, et al.
J Virol
. 2001 Jan;
75(2):687-98.
PMID: 11134282
Packaging of DNA into preformed capsids is a fundamental early event in the assembly of herpes simplex virus type 1 (HSV-1) virions. Replicated viral DNA genomes, in the form of...
6.
Sheaffer A, Newcomb W, Brown J, Gao M, Weller S, Tenney D
J Virol
. 2000 Jul;
74(15):6838-48.
PMID: 10888623
Herpes simplex virus type 1 (HSV-1) capsids are initially assembled with an internal protein scaffold. The scaffold proteins, encoded by overlapping in-frame UL26 and UL26.5 transcripts, are essential for formation...
7.
Newcomb W, Trus B, Cheng N, Steven A, Sheaffer A, Tenney D, et al.
J Virol
. 2000 Jan;
74(4):1663-73.
PMID: 10644336
Herpes simplex virus type 1 (HSV-1) capsid proteins assemble in vitro into spherical procapsids that differ markedly in structure and stability from mature polyhedral capsids but can be converted to...
8.
Newcomb W, Homa F, Thomsen D, Trus B, Cheng N, Steven A, et al.
J Virol
. 1999 Apr;
73(5):4239-50.
PMID: 10196320
An in vitro system is described for the assembly of herpes simplex virus type 1 (HSV-1) procapsids beginning with three purified components, the major capsid protein (VP5), the triplexes (VP19C...
9.
Functional conservations of the alkaline nuclease of herpes simplex type 1 and human cytomegalovirus
Gao M, Robertson B, McCann P, OBoyle D, Weller S, Newcomb W, et al.
Virology
. 1998 Oct;
249(2):460-70.
PMID: 9791036
The herpes simplex virus type 1 UL12 gene product, alkaline nuclease (AN), appears to be involved in viral DNA processing and capsid egress from the nucleus (Shao, L., Rapp, L....
10.
Spencer J, Newcomb W, Thomsen D, Homa F, Brown J
J Virol
. 1998 Apr;
72(5):3944-51.
PMID: 9557680
The herpes simplex virus type 1 (HSV-1) capsid is a T=16 icosahedral shell that forms in the nuclei of infected cells. Capsid assembly also occurs in vitro in reaction mixtures...