W P Walters
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Explore the profile of W P Walters including associated specialties, affiliations and a list of published articles.
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7
Citations
275
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Recent Articles
1.
ter Haar E, Walters W, Pazhanisamy S, Taslimi P, Pierce A, Bemis G, et al.
Mini Rev Med Chem
. 2004 Mar;
4(3):235-53.
PMID: 15032672
Chemogenomics is a gene family-based approach to drug discovery and target validation. This review will summarize the application of this interdisciplinary approach to the protein kinases of the human genome...
2.
Charifson P, Corkery J, Murcko M, Walters W
J Med Chem
. 1999 Dec;
42(25):5100-9.
PMID: 10602695
We present the results of an extensive computational study in which we show that combining scoring functions in an intersection-based consensus approach results in an enhancement in the ability to...
3.
Walters W, Ajay , Murcko M
Curr Opin Chem Biol
. 1999 Jul;
3(4):384-7.
PMID: 10419858
A variety of successful approaches to the problem of recognizing 'drug-like' molecules have been employed. These range from simple counting schemes such as the Lipinski 'rule of five' to the...
4.
Ajay A, Walters W, Murcko M
J Med Chem
. 1998 Aug;
41(18):3314-24.
PMID: 9719583
We have used a Bayesian neural network to distinguish between drugs and nondrugs. For this purpose, the CMC acts as a surrogate for drug-like molecules while the ACD is a...
5.
Walters W, Dolata D
J Mol Graph
. 1994 Jun;
12(2):130-8.
PMID: 7918251
MOUSE-III is learning program that finds rules of conformational analysis from raw crystallographic data. The program perceives molecular features, finds conformational classes in the data and then learns rules that...
6.
Dolata D, Walters W
J Mol Graph
. 1993 Jun;
11(2):112-7.
PMID: 8347563
A method for learning short-term rules of conformational analysis is introduced. The technique works by discovering problems during the building of a conformation in Cartesian coordinate space, and builds an...
7.
Dolata D, Walters W
J Mol Graph
. 1993 Jun;
11(2):106-11.
PMID: 8347562
MOUSE is a teachable program which learns concepts of conformational analysis from examples obtained from WIZARD. The algorithms are presented, and a fully worked example is used to demonstrate how...