W K Hildner
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Explore the profile of W K Hildner including associated specialties, affiliations and a list of published articles.
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10
Citations
82
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Recent Articles
1.
Broner C, Shenep J, Stokes D, Fairclough D, Hildner W, Storgion S, et al.
J Infect Dis
. 1993 Jan;
167(1):141-7.
PMID: 8380289
Septic shock occurs when endotoxin and other bacterial substances induce the release of host products that act in concert to alter the circulation. Recently, investigators have speculated that endothelium-derived relaxing...
2.
Bysani G, Stokes D, Fishman M, Shenep J, Hildner W, Rufus K, et al.
J Infect Dis
. 1990 Oct;
162(4):939-43.
PMID: 2169501
The specific binding of radiolabeled polymyxin B (PmB) to rat alveolar macrophages was investigated. PmB retained its ability to inhibit lipopolysaccharide-induced tumor necrosis factor production by macrophages as long as...
3.
Bysani G, Shenep J, Hildner W, Stidham G, Roberson P
Crit Care Med
. 1990 Jan;
18(1):67-71.
PMID: 2403508
We compared the ability of 13 materials, all with known affinity for lipopolysaccharide (LPS), to remove LPS from water, pooled normal human plasma, and plasma from a patient with Gram-negative...
4.
Broner C, Shenep J, Stidham G, Stokes D, Fairclough D, SCHONBAUM G, et al.
Circ Shock
. 1989 Oct;
29(2):77-92.
PMID: 2684447
Free radicals have been implicated in the pathogenesis of gram-negative bacterial sepsis. We assessed the effectiveness of antioxidants and chelators to alter oxidative injury in established severe experimental Escherichia coli...
5.
Stokes D, Shenep J, Fishman M, Hildner W, Bysani G, Rufus K
J Infect Dis
. 1989 Jul;
160(1):52-7.
PMID: 2543712
Polymyxin B (PmB) blocks many of the toxic effects of lipopolysaccharide by mechanisms that are not yet understood. The production of tumor necrosis factor-alpha (TNF-alpha) by isolated rat alveolar macrophages...
6.
Flynn P, Shenep J, Gigliotti F, Davis D, Hildner W
Infect Immun
. 1988 Oct;
56(10):2760-2.
PMID: 3047065
Increased anti-core glycolipid antibody binding was visualized by immunoelectron microscopy after incubation of Escherichia coli K1:O7 cells with a bacteriolytic antibiotic and compared with binding in control cells. The findings...
7.
Broner C, Shenep J, Stidham G, Stokes D, Hildner W
Crit Care Med
. 1988 Sep;
16(9):848-51.
PMID: 3042286
Oxygen-derived free radicals have been implicated as mediators of cellular injury in several model systems. Recently, a role for free radicals has been proposed in the mortality associated with Gram-negative...
8.
Polymyxin B moderates acidosis and hypotension in established, experimental gram-negative septicemia
Flynn P, Shenep J, Stokes D, Fairclough D, Hildner W
J Infect Dis
. 1987 Nov;
156(5):706-12.
PMID: 2821123
Polymyxin B (PMB), an antibiotic, and sodium deoxycholate (NaD), a bile salt, are surface-active agents. Each protected mice against an otherwise lethal challenge with purified endotoxin (P less than .001)....
9.
Shenep J, Gigliotti F, Davis D, Hildner W
Rev Infect Dis
. 1987 Sep;
9 Suppl 5:S639-43.
PMID: 2446371
Studies of the cross-reactivity of antibodies to core glycolipid with assorted isolated, heterologous lipopolysaccharides (LPSs) confirm the conservation of core glycolipid epitopes among gram-negative bacterial species. However, the accessibility of...
10.
Flynn P, Shenep J, Stokes D, Hildner W, Mackert P, Snellgrove R, et al.
Infect Immun
. 1986 Apr;
52(1):26-30.
PMID: 3957427
To determine the effect of methylprednisolone administration on the clearance of bacteremia and the release and clearance of endotoxin during antibiotic therapy of gram-negative bacterial sepsis, Escherichia coli K1 sepsis...