W H Lyness
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Explore the profile of W H Lyness including associated specialties, affiliations and a list of published articles.
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42
Citations
284
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Recent Articles
1.
Sachdeo R, Wagner M, Sachdeo S, Shumaker R, Lyness W, Rosenberg A, et al.
Epilepsia
. 1999 Aug;
40(8):1122-8.
PMID: 10448826
Purpose: This open-label study investigated the pharmacokinetic interaction of phenytoin (PHT) and felbamate (FBM). Methods: Ten subjects with epilepsy receiving PHT monotherapy were administered increasing doses of FBM (1,200, 1,800,...
2.
Evaluation of the potential interaction between felbamate and erythromycin in patients with epilepsy
Sachdeo R, Montgomery P, Shumaker R, Perhach J, Lyness W, Rosenberg A
J Clin Pharmacol
. 1998 Apr;
38(2):184-90.
PMID: 9549651
Effects of erythromycin on hepatic CYP450 3A4 isozymes can profoundly influence the metabolism of many therapeutic agents. An open-label, randomized, two-period, crossover study was therefore conducted to evaluate the pharmacokinetics...
3.
Morganroth J, Lyness W, Perhach J, Mather G, Harr J, TRAGER W, et al.
J Clin Pharmacol
. 1998 Mar;
37(11):1065-72.
PMID: 9506001
Azelastine, an antihistamine with additional pharmacologic properties, was evaluated for a possible influence on pharmacokinetic and electrocardiographic parameters due to its coadministration with CYP3A4 inhibitor ketoconazole (200 mg every 12...
4.
Sachdeo R, Shumaker R, Perhach J, Lyness W, Rosenberg A
Epilepsia
. 1997 Aug;
38(8):887-92.
PMID: 9579889
Purpose: Felbamate (FBM) pharmacokinetic parameters, safety and tolerability in the dose range of 1,200-6,000 mg/day were assessed in two open-label studies with similar designs. Methods: In study A, newly diagnosed...
5.
Kurth M, Tetrud J, Irwin I, Lyness W, Langston J
Neurology
. 1993 May;
43(5):1036-9.
PMID: 8492922
Four patients with Parkinson's disease, optimally treated with levodopa/carbidopa (LD/CD) tablets but experiencing severe motor fluctuations, underwent an open trial of a levodopa/carbidopa/ascorbic acid solution (LCAS) orally at timed intervals....
6.
Lyness W, Smith F
Pharmacol Biochem Behav
. 1992 May;
42(1):187-92.
PMID: 1388276
Rats implanted with chronic indwelling intravenous catheters and allowed access to a self-administration apparatus learned to self-inject intravenous ethanol. Ethanol concentrations of 0.5, 1.0, and 2.0%, corresponding to a dose/injection...
7.
Lyness W, Smith F, Heavner J, Iacono C, Garvin R
Life Sci
. 1989 Jan;
45(23):2217-24.
PMID: 2601574
Rats injected with Freund's adjuvant develop a syndrome resembling human rheumatoid arthritis complete with paw swelling, edema and persistent pain. At the onset of pain, arthritic rats and their pain-free...
8.
Smith F, St John C, Yang T, Lyness W
Psychopharmacology (Berl)
. 1989 Jan;
97(4):501-6.
PMID: 2567031
Biochemical, electrophysiological, and behavioral experiments suggest that the dopamine D-1 and D-2 receptor subtypes functionally interact. In rats trained to discriminate 1.0 mg/kg d-amphetamine, substitution with the D-2 agonist quinpirole...
9.
Leccese A, Lyness W
Neuropharmacology
. 1987 Sep;
26(9):1303-8.
PMID: 3118232
It has been suggested that dopamine (DA)-containing neurons within the medial prefrontal cortex subserve a role in the positive reinforcing effects of psychomotor stimulants. Injections of 6-hydroxydopamine (6-OHDA) into this...
10.
Geis L, Smith D, Smith F, Yu D, Lyness W
Pharmacol Biochem Behav
. 1986 Nov;
25(5):1027-33.
PMID: 3786355
Earlier work had shown that L-tyrosine administration, precursor to both dopamine (DA) and norepinephrine (NE), could increase brain DA metabolite concentrations after amphetamine treatment and restore amphetamine-induced decreases in whole...