W E Goldman
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Explore the profile of W E Goldman including associated specialties, affiliations and a list of published articles.
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57
Citations
1543
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Recent Articles
1.
Almeida A, Carmona J, Cunha C, Carvalho A, Rappleye C, Goldman W, et al.
Fungal Genet Biol
. 2007 May;
44(12):1387-98.
PMID: 17512227
We herein report the development of a molecular toolbox for the dimorphic fungus Paracoccidioides brasiliensis, specifically a more efficient transformation and a gene expression system. We evaluated several parameters that...
2.
Magrini V, Goldman W
Trends Microbiol
. 2002 Feb;
9(11):541-6.
PMID: 11825714
Research in medical mycology has traditionally been a mix of exciting biology and frustrating genetics, although the excitement has been steadily increasing as genetic obstacles have been successfully overcome. Now,...
3.
Kugler S, Young B, Miller V, Goldman W
Cell Microbiol
. 2001 Feb;
2(6):537-47.
PMID: 11207606
Dimorphism is an essential feature of Histoplasma capsulatum pathogenesis, and much attention has been focused on characteristics that are unique to the saprophytic mycelial phase or the parasitic yeast phase....
4.
Flak T, Goldman W
Cell Microbiol
. 2001 Feb;
1(1):51-60.
PMID: 11207540
Bordetella pertussis, the aetiological agent of whooping cough (pertussis), causes selective destruction of ciliated cells of the human airway mucosa. In a hamster tracheal organ culture model, B. pertussis causes...
5.
Sebghati T, Engle J, Goldman W
Science
. 2000 Nov;
290(5495):1368-72.
PMID: 11082066
Histoplasma capsulatum is an effective intracellular parasite of macrophages and causes the most prevalent fungal respiratory disease in the United States. A "dimorphic" fungus, H. capsulatum exists as a saprophytic...
6.
Beckett C, Loughman J, Karberg K, Donato G, Goldman W, Kranz R
Mol Microbiol
. 2000 Nov;
38(3):465-81.
PMID: 11069671
Unlike other cytochromes, c-type cytochromes have two covalent bonds formed between the two vinyl groups of haem and two cysteines of the protein. This haem ligation requires specific assembly proteins...
7.
Kugler S, Schurtz Sebghati T, Groppe Eissenberg L, Goldman W
Proc Natl Acad Sci U S A
. 2000 Aug;
97(16):8794-8.
PMID: 10922037
The success of Histoplasma capsulatum as an intracellular pathogen depends completely on successful conversion of the saprophytic mycelial (mold) form of this fungus to a parasitic yeast form. It is...
8.
Flak T, Heiss L, Engle J, Goldman W
Infect Immun
. 2000 Feb;
68(3):1235-42.
PMID: 10678932
We have investigated the synergistic interactions of a naturally occurring peptidoglycan fragment (muramyl peptide) and bacterial endotoxin in the induction of inflammatory processes within respiratory epithelial cells, at the levels...
9.
10.
Kwon-Chung K, Goldman W, Klein B, Szaniszlo P
Med Mycol
. 1999 Feb;
36 Suppl 1:38-44.
PMID: 9988490
Genetic engineering is an important tool in helping us to define the molecular basis of pathogenicity and is also useful in helping us to identify new therapeutic targets in pathogenic...