W D Hirst
Overview
Explore the profile of W D Hirst including associated specialties, affiliations and a list of published articles.
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19
Citations
576
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Recent Articles
1.
Adler C, Beach T, Shill H, Caviness J, Driver-Dunckley E, Sabbagh M, et al.
Eur J Neurol
. 2017 Aug;
24(11):1363-1368.
PMID: 28834018
Background And Purpose: Mutations in the glucocerebrosidase (GBA) gene are known to be a risk factor for Parkinson's disease (PD). Data on clinicopathological correlation are limited. The purpose of this...
2.
Garcia-Alloza M, Hirst W, Chen C, Lasheras B, Francis P, Ramirez M
Neuropsychopharmacology
. 2003 Oct;
29(2):410-6.
PMID: 14571255
Growing evidence suggests that a compromised serotonergic system plays an important role in the pathophysiology of Alzheimer's disease (AD). We assessed the expression of 5-HT(1B/1D) and 5-HT(6) receptors and cholinacetyltransferase...
3.
Couve A, Thomas P, Calver A, Hirst W, Pangalos M, Walsh F, et al.
Nat Neurosci
. 2002 Apr;
5(5):415-24.
PMID: 11976702
GABA (gamma-aminobutyric acid)(B) receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Here we show that the functional coupling of GABA(B)R1/GABA(B)R2 receptors to...
4.
Lanneau C, Green A, Hirst W, Wise A, Brown J, Donnier E, et al.
Neuropharmacology
. 2001 Dec;
41(8):965-75.
PMID: 11747901
Recent experiments have demonstrated that formation of functional type B gamma-aminobutyric acid (GABA(B)) receptors requires co-expression of two receptor subunits, GABA(B1) and GABA(B2). Despite the identification of these subunits and...
5.
Robbins M, Calver A, Filippov A, Hirst W, Russell R, Wood M, et al.
J Neurosci
. 2001 Oct;
21(20):8043-52.
PMID: 11588177
GABA(B) receptors are unique among G-protein-coupled receptors (GPCRs) in their requirement for heterodimerization between two homologous subunits, GABA(B1) and GABA(B2), for functional expression. Whereas GABA(B1) is capable of binding receptor...
6.
Prosser H, Gill C, Hirst W, Grau E, Robbins M, Calver A, et al.
Mol Cell Neurosci
. 2001 Jun;
17(6):1059-70.
PMID: 11414794
The recent cloning of two GABA(B) receptor subunits, GABA(B1) and GABA(B2), has raised the possibility that differences in GABA(B) receptor subunit composition may give rise to pharmacologically or functionally distinct...
7.
Read S, Hirst W, Upton N, Parsons A
Brain Res
. 2001 Feb;
891(1-2):69-77.
PMID: 11164810
Migraine headache is proposed to be mediated by nitric oxide (NO). Suitable mechanisms for eliciting increases in brain NO concentration in migraineurs have not yet been identified, although, animal models...
8.
Calver A, Robbins M, Cosio C, Rice S, Babbs A, Hirst W, et al.
J Neurosci
. 2001 Feb;
21(4):1203-10.
PMID: 11160390
GABA(B) receptors are G-protein-coupled receptors that mediate slow synaptic inhibition in the brain and spinal cord. These receptors are heterodimers assembled from GABA(B1) and GABA(B2) subunits, neither of which is...
9.
Wood M, Murkitt K, Rice S, Testa T, Punia P, STAMMERS M, et al.
Br J Pharmacol
. 2000 Nov;
131(6):1050-4.
PMID: 11082110
1. The aim of this study was to characterize the pharmacological profile of the GABA(B1)/GABA(B2) heterodimeric receptor expressed in Chinese hamster ovary (CHO) cells. We have compared receptor binding affinity...
10.
Langmead C, Szekeres P, Chambers J, Ratcliffe S, Jones D, Hirst W, et al.
Br J Pharmacol
. 2000 Oct;
131(4):683-8.
PMID: 11030716
GPR10 is a novel G-protein coupled receptor that is the human orthologue of rat Unknown Hypothalamic Receptor-1 (UHR-1). Human prolactin-releasing peptide (PrRP) has been identified as an endogenous ligand for...