Vladislav V Mokhonov
Overview
Explore the profile of Vladislav V Mokhonov including associated specialties, affiliations and a list of published articles.
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14
Citations
259
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Recent Articles
1.
Vasilenko E, Gorshkova E, Astrakhantseva I, Drutskaya M, Tillib S, Nedospasov S, et al.
FEBS Lett
. 2020 Sep;
594(21):3542-3550.
PMID: 32865225
Spatial organization and conformational changes of antibodies may significantly affect their biological functions. We assessed the effect of mutual organization of the two V H domains within bispecific antibodies recognizing...
2.
Drutskaya M, Nosenko M, Gorshkova E, Mokhonov V, Zvartsev R, Polinova A, et al.
J Leukoc Biol
. 2020 Feb;
107(6):933-939.
PMID: 32040234
Systemic TNF neutralization can be used as a therapy for several autoimmune diseases. To evaluate the effects of cell type-restricted TNF blockade, we previously generated bispecific antibodies that can limit...
3.
Nosenko M, Atretkhany K, Mokhonov V, Vasilenko E, Kruglov A, Tillib S, et al.
Semin Arthritis Rheum
. 2019 Nov;
49(3S):S39-S42.
PMID: 31779851
In spite of successful therapeutic neutralization of proinflammatory cytokines in several autoimmune diseases, such therapy is not entirely free of side effects. The main reason relates to the fact that...
4.
Gorshkova E, Efimov G, Ermakova K, Vasilenko E, Yuzhakova D, Shirmanova M, et al.
Antibodies (Basel)
. 2019 Sep;
7(4).
PMID: 31544893
Upregulation of the expression of tumor necrosis factor (TNF-α, TNF) has a significant role in the development of autoimmune diseases. The fluorescent antibodies binding TNF may be used for personalized...
5.
Mokhonov V, Vasilenko E, Gorshkova E, Astrakhantseva I, Novikov D, Novikov V
Biochem Biophys Res Commun
. 2018 Apr;
499(4):967-972.
PMID: 29626483
Binding of native bacterial protein SlyD to metal affinity matrices remains a major problem in affinity purification of His-tagged recombinant proteins from Escherichia coli cells. In this study, four novel...
6.
Nosenko M, Atretkhany K, Mokhonov V, Efimov G, Kruglov A, Tillib S, et al.
Front Immunol
. 2017 Sep;
8:1073.
PMID: 28919896
Proinflammatory cytokines, such as TNF, IL-6, and IL-1, play pathogenic roles in multiple diseases and are attractive targets for biologic drugs. Because proinflammatory cytokines possess non-redundant protective and immunoregulatory functions,...
7.
Efimov G, Kruglov A, Khlopchatnikova Z, Rozov F, Mokhonov V, Rose-John S, et al.
Proc Natl Acad Sci U S A
. 2016 Mar;
113(11):3006-11.
PMID: 26936954
Overexpression of TNF contributes to pathogenesis of multiple autoimmune diseases, accounting for a remarkable success of anti-TNF therapy. TNF is produced by a variety of cell types, and it can...
8.
Mokhonov V, Theendakara V, Gribanova Y, Ahmedli N, Farber D
PLoS One
. 2012 Jun;
7(5):e35317.
PMID: 22693546
Zbed4, a member of the BED subclass of Zinc-finger proteins, is expressed in cone photoreceptors and glial Müller cells of human retina whereas it is only present in Müller cells...
9.
Anraku I, Mokhonov V, Rattanasena P, Mokhonova E, Leung J, Pijlman G, et al.
Vaccine
. 2008 May;
26(26):3268-76.
PMID: 18462846
An RNA-based, non-cytopathic replicon vector system, based on the flavivirus Kunjin, has shown considerable promise as a new vaccine delivery system. Here we describe the testing in mice of four...
10.
Liu W, Wang X, Mokhonov V, Shi P, Randall R, Khromykh A
J Virol
. 2005 Jan;
79(3):1934-42.
PMID: 15650219
The interferon (IFN) response is the first line of defense against viral infections, and the majority of viruses have developed different strategies to counteract IFN responses in order to ensure...