Vitold E Galkin
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Explore the profile of Vitold E Galkin including associated specialties, affiliations and a list of published articles.
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65
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2138
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Recent Articles
1.
Little M, Risi C, Larrinaga T, Summers M, Summers M, Nguyen T, et al.
PLoS Biol
. 2025 Jan;
23(1):e3003027.
PMID: 39883708
Every heartbeat depends on cyclical contraction-relaxation produced by the interactions between myosin-containing thick and actin-based thin filaments (TFs) arranged into a crystalline-like lattice in the cardiac sarcomere. Therefore, the maintenance...
2.
Risi C, Belknap B, Atherton J, Coscarella I, White H, Bryant Chase P, et al.
J Mol Biol
. 2024 Feb;
436(6):168498.
PMID: 38387550
Cardiac muscle contraction occurs due to repetitive interactions between myosin thick and actin thin filaments (TF) regulated by Ca levels, active cross-bridges, and cardiac myosin-binding protein C (cMyBP-C). The cardiac...
3.
Landim-Vieira M, Ma W, Song T, Rastegarpouyani H, Gong H, Coscarella I, et al.
Proc Natl Acad Sci U S A
. 2023 May;
120(23):e2221244120.
PMID: 37252999
Missense variant Ile79Asn in human cardiac troponin T (cTnT-I79N) has been associated with hypertrophic cardiomyopathy and sudden cardiac arrest in juveniles. cTnT-I79N is located in the cTnT N-terminal (TnT1) loop...
4.
Risi C, Belknap B, White H, Dryden K, Pinto J, Bryant Chase P, et al.
PNAS Nexus
. 2023 Jan;
2(1):pgac298.
PMID: 36712934
Cardiac contraction depends on molecular interactions among sarcomeric proteins coordinated by the rising and falling intracellular Ca levels. Cardiac thin filament (cTF) consists of two strands composed of actin, tropomyosin...
5.
Risi C, Villanueva E, Belknap B, Sadler R, Harris S, White H, et al.
J Mol Biol
. 2022 Nov;
434(24):167879.
PMID: 36370805
Cardiac myosin binding protein C (cMyBP-C) modulates cardiac contraction via direct interactions with cardiac thick (myosin) and thin (actin) filaments (cTFs). While its C-terminal domains (e.g. C8-C10) anchor cMyBP-C to...
6.
Pepper I, Galkin V
Subcell Biochem
. 2022 Sep;
99:421-470.
PMID: 36151385
Formation of cross-bridges between actin and myosin occurs ubiquitously in eukaryotic cells and mediates muscle contraction, intracellular cargo transport, and cytoskeletal remodeling. Myosin motors repeatedly bind to and dissociate from...
7.
Smith G, Tolkatchev D, Risi C, Little M, Gregorio C, Galkin V, et al.
Protein Sci
. 2022 Jun;
31(7):e4358.
PMID: 35762710
A transient increase in Ca concentration in sarcomeres is essential for their proper function. Ca drives striated muscle contraction via binding to the troponin complex of the thin filament to...
8.
Correll V, Otto J, Risi C, Main B, Boutros P, Kislinger T, et al.
J Extracell Vesicles
. 2022 Feb;
11(2):e12184.
PMID: 35119778
The isolation and subsequent molecular analysis of extracellular vesicles (EVs) derived from patient samples is a widely used strategy to understand vesicle biology and to facilitate biomarker discovery. Expressed prostatic...
9.
Risi C, Patra M, Belknap B, Harris S, White H, Galkin V
J Mol Biol
. 2021 Jul;
433(19):167178.
PMID: 34329643
Cardiac muscle contraction depends on interactions between thick (myosin) and thin (actin) filaments (TFs). TFs are regulated by intracellular Ca levels. Under activating conditions Ca binds to the troponin complex...
10.
Marques M, Landim-Vieira M, Moraes A, Sun B, Johnston J, Jones K, et al.
Chem Sci
. 2021 Jun;
12(21):7308-7323.
PMID: 34163821
Cardiac TnC (cTnC) is highly conserved among mammals, and genetic variants can result in disease by perturbing Ca-regulation of myocardial contraction. Here, we report the molecular basis of a human...