Vincent Muczynski
Overview
Explore the profile of Vincent Muczynski including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
345
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0
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Recent Articles
1.
Muczynski V, Nathwani A
Thromb Res
. 2024 Feb;
236:242-249.
PMID: 38383218
Early gene therapy clinical trials for the treatment of Haemophilia B have been instrumental to our global understanding of gene therapy and have significantly contributed to the rapid expansion of...
2.
Sefiane T, Maynadie H, Ettingshausen C, Muczynski V, Heiligenstein X, Dumont J, et al.
Haematologica
. 2023 Dec;
109(6):1836-1848.
PMID: 38058210
Recombinant factor VIII (rFVIII), rFVIIIFc and emicizumab are established treatment options in the management of hemophilia A. Each has its unique mode of action, which can influence thrombin generation kinetics...
3.
Harrasser M, Gohil S, Lau H, Della Peruta M, Muczynski V, Patel D, et al.
Breast Cancer Res
. 2022 Jun;
24(1):39.
PMID: 35659040
Background: Chimeric antigen receptor (CAR)-T cells can induce powerful immune responses in patients with hematological malignancies but have had limited success against solid tumors. This is in part due to...
4.
Wohner N, Sebastian S, Muczynski V, Huskens D, de Laat B, de Groot P, et al.
J Thromb Haemost
. 2021 Nov;
20(3):755-766.
PMID: 34816579
Background: Platelet-binding Von Willebrand Factor (VWF) strings assemble upon stimulated secretion from endothelial cells. Objectives: To investigate the efficiency of platelet binding to multi-molecular VWF bundles secreted from endothelial cells...
5.
Lagrange J, Worou M, Michel J, Raoul A, Didelot M, Muczynski V, et al.
Cardiovasc Res
. 2021 Feb;
118(2):622-637.
PMID: 33576766
Aims: Von Willebrand factor (VWF) is a plasma glycoprotein involved in primary haemostasis, while also having additional roles beyond haemostasis namely in cancer, inflammation, angiogenesis, and potentially in vascular smooth...
6.
Ferriere S, Peyron I, Christophe O, Kawecki C, Casari C, Muczynski V, et al.
Blood
. 2020 May;
136(6):740-748.
PMID: 32369559
The bispecific antibody emicizumab is increasingly used for hemophilia A treatment. However, its specificity for human factors IX and X (FIX and FX) has limited its in vivo functional analysis...
7.
Muczynski V, Verhenne S, Casari C, Cherel G, Panicot-Dubois L, Gueguen P, et al.
Thromb Haemost
. 2019 Oct;
119(12):1981-1993.
PMID: 31639831
Engineered recombinant factor X (FX) variants represent a promising strategy to bypass the tenase complex and restore hemostasis in hemophilia patients. Previously, a thrombin-activatable FX variant with fibrinopeptide-A replacing the...
8.
Muczynski V, Casari C, Moreau F, Ayme G, Kawecki C, Legendre P, et al.
Blood
. 2018 Aug;
132(11):1193-1197.
PMID: 30064978
Von Willebrand factor (VWF) modulates factor VIII (FVIII) clearance and the anti-FVIII immune response. Despite the high affinity that defines the FVIII/VWF interaction, association/dissociation kinetics dictates 2% to 5% FVIII...
9.
Wohner N, Muczynski V, Mohamadi A, Legendre P, Proulle V, Ayme G, et al.
Haematologica
. 2018 Jan;
103(4):728-737.
PMID: 29326120
Previously, we found that LDL-receptor related protein-1 on macrophages mediated shear stress-dependent clearance of von Willebrand factor. In control experiments, however, we observed that von Willebrand factor also binds to...
10.
Muczynski V, Christophe O, Denis C, Lenting P
Semin Thromb Hemost
. 2017 Jul;
43(6):581-590.
PMID: 28750425
No abstract available.