Vijay K Yechoor
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Explore the profile of Vijay K Yechoor including associated specialties, affiliations and a list of published articles.
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32
Citations
979
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Recent Articles
1.
Aleman J, K R, Wiegand C, Schurdak M, Vernetti L, Gavlock D, et al.
Commun Biol
. 2024 Oct;
7(1):1317.
PMID: 39397070
Preclinical and clinical studies suggest that lipid-induced hepatic insulin resistance is a primary defect that predisposes to dysfunction in islets, implicating a perturbed liver-pancreas axis underlying the comorbidity of T2DM...
2.
Goo Y, Ayyappan J, Cheeran F, Bangru S, Saha P, Baar P, et al.
Nat Commun
. 2024 Aug;
15(1):6540.
PMID: 39095402
Foam cells in atheroma are engorged with lipid droplets (LDs) that contain esters of regulatory lipids whose metabolism remains poorly understood. LD-associated hydrolase (LDAH) has a lipase structure and high...
3.
Negi V, Lee J, Mandi V, Danvers J, Liu R, Perez-Garcia E, et al.
Cells
. 2024 Jul;
13(13).
PMID: 38994961
Cytokine-induced β-cell apoptosis is a major pathogenic mechanism in type 1 diabetes (T1D). Despite significant advances in understanding its underlying mechanisms, few drugs have been translated to protect β-cells in...
4.
Negi V, Gavlock D, Miedel M, Lee J, Shun T, Gough A, et al.
Lab Chip
. 2023 Sep;
23(20):4514-4527.
PMID: 37766577
: COVID-19 pandemic has caused more than 6 million deaths worldwide. Co-morbid conditions such as Type 2 Diabetes (T2D) have increased mortality in COVID-19. With limited translatability of and small...
5.
Li F, Liu R, Negi V, Yang P, Lee J, Jagannathan R, et al.
Cell Rep
. 2023 Jan;
42(1):111904.
PMID: 36662616
TEAD1 and the mammalian Hippo pathway regulate cellular proliferation and function, though their regulatory function in β cells remains poorly characterized. In this study, we demonstrate that while β cell-specific...
6.
Li F, Negi V, Yang P, Lee J, Ma K, Moulik M, et al.
Nucleic Acids Res
. 2022 Dec;
50(22):12723-12738.
PMID: 36484096
The Hippo-TEAD pathway regulates cellular proliferation and function. The existing paradigm is that TEAD co-activators, YAP and TAZ, and co-repressor, VGLL4, bind to the pocket region of TEAD1 to enable...
7.
Aslanoglou D, Bertera S, Friggeri L, Sanchez-Soto M, Lee J, Xue X, et al.
iScience
. 2022 Aug;
25(8):104771.
PMID: 35982797
Bromocriptine is approved as a diabetes therapy, yet its therapeutic mechanisms remain unclear. Though bromocriptine's actions have been mainly attributed to the stimulation of brain dopamine D receptors (D2R), bromocriptine...
8.
Lefever D, Miedel M, Pei F, DiStefano J, DeBiasio R, Shun T, et al.
Metabolites
. 2022 Jun;
12(6).
PMID: 35736460
Non-alcoholic fatty liver disease (NAFLD) has a high global prevalence with a heterogeneous and complex pathophysiology that presents barriers to traditional targeted therapeutic approaches. We describe an integrated quantitative systems...
9.
Chatterjee S, Yin H, Li W, Lee J, Yechoor V, Ma K
Sci Rep
. 2022 Mar;
12(1):4848.
PMID: 35318340
No abstract available.
10.
Aslanoglou D, Bertera S, Sanchez-Soto M, Free R, Lee J, Zong W, et al.
Transl Psychiatry
. 2021 Feb;
11(1):59.
PMID: 33589583
Dopamine (DA) and norepinephrine (NE) are catecholamines primarily studied in the central nervous system that also act in the pancreas as peripheral regulators of metabolism. Pancreatic catecholamine signaling has also...