Victoria Offord
Overview
Explore the profile of Victoria Offord including associated specialties, affiliations and a list of published articles.
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Articles
20
Citations
257
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0
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Recent Articles
1.
van der Weyden L, Del Castillo Velasco-Herrera M, Cheema S, Wong K, Boccacino J, Vermes I, et al.
Br J Dermatol
. 2024 Nov;
192(3):551-553.
PMID: 39506538
No abstract available.
2.
van der Weyden L, Del Castillo Velasco-Herrera M, Cheema S, Wong K, Boccacino J, Offord V, et al.
Br J Dermatol
. 2024 Oct;
192(2):335-343.
PMID: 39392932
Background: Cutaneous leiomyosarcoma (cLMS) is a rare soft-tissue neoplasm, showing smooth muscle differentiation, that arises from the mesenchymal cells of the dermis. To date, genetic investigation of these tumours has...
3.
Olvera-Leon R, Zhang F, Offord V, Zhao Y, Tan H, Gupta P, et al.
Cell
. 2024 Sep;
187(20):5719-5734.e19.
PMID: 39299233
Pathogenic variants in RAD51C confer an elevated risk of breast and ovarian cancer, while individuals homozygous for specific RAD51C alleles may develop Fanconi anemia. Using saturation genome editing (SGE), we...
4.
Waters A, Brendler-Spaeth T, Smith D, Offord V, Tan H, Zhao Y, et al.
Nat Genet
. 2024 Jul;
56(7):1434-1445.
PMID: 38969833
Many variants that we inherit from our parents or acquire de novo or somatically are rare, limiting the precision with which we can associate them with disease. We performed exhaustive...
5.
Lu Z, Sankaranarayanan G, Rawlinson K, Offord V, Brindley P, Berriman M, et al.
Front Trop Dis
. 2022 Nov;
2:713123.
PMID: 36389622
Schistosomiasis, the most important helminthic disease of humanity, is caused by infection with parasitic flatworms of the genus . The disease is driven by parasite eggs becoming trapped in host...
6.
Valcarcel-Jimenez L, Rogerson C, Yong C, Schmidt C, Yang M, Cremades-Rodelgo M, et al.
Sci Adv
. 2022 Oct;
8(42):eabq8297.
PMID: 36269833
Fumarate hydratase (FH) is a mitochondrial enzyme that catalyzes the reversible hydration of fumarate to malate in the tricarboxylic acid (TCA) cycle. Germline mutations of lead to hereditary leiomyomatosis and...
7.
Barbon L, Offord V, Radford E, Butler A, Gerety S, Adams D, et al.
Bioinformatics
. 2021 Nov;
38(4):892-899.
PMID: 34791067
Motivation: CRISPR/Cas9-based technology allows for the functional analysis of genetic variants at single nucleotide resolution whilst maintaining genomic context. This approach, known as saturation genome editing (SGE), a form of...
8.
van der Weyden L, Offord V, Turner G, Swiatkowska A, Speak A, Adams D
G3 (Bethesda)
. 2021 May;
11(7).
PMID: 33963380
Metastasis is the spread of cancer cells to a secondary site within the body, and is the leading cause of death for cancer patients. The lung is a common site...
9.
van der Weyden L, Harle V, Turner G, Offord V, Iyer V, Droop A, et al.
Commun Biol
. 2021 Mar;
4(1):395.
PMID: 33758365
Melanoma represents ~5% of all cutaneous malignancies, yet accounts for the majority of skin cancer deaths due to its propensity to metastasise. To develop new therapies, novel target molecules must...
10.
Thompson N, Ranzani M, van der Weyden L, Iyer V, Offord V, Droop A, et al.
Nat Commun
. 2021 Feb;
12(1):1302.
PMID: 33637726
Genetic redundancy has evolved as a way for human cells to survive the loss of genes that are single copy and essential in other organisms, but also allows tumours to...