Vetrivel Umashankar
Overview
Explore the profile of Vetrivel Umashankar including associated specialties, affiliations and a list of published articles.
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Articles
30
Citations
147
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Recent Articles
1.
Hemavathy N, Umashankar V, Jeyakanthan J
Comput Biol Chem
. 2024 Dec;
115:108289.
PMID: 39631222
LIMK2 is crucial in regulating actin cytoskeleton dynamics, significantly contributing to cancer cell proliferation, invasion, and metastasis. Inhibitors like LIMKi3 effectively suppress LIMK2 kinase activity by directly affecting actin polymerization...
2.
Rangaswamy R, Sneha S, Hemavathy N, Umashankar V, Jeyakanthan J
Mol Divers
. 2024 Jul;
29(2):1287-1303.
PMID: 38970640
Rheumatoid Arthritis (RA) is a chronic, symmetrical inflammatory autoimmune disorder characterized by painful, swollen synovitis and joint erosions, which can cause damage to bone and cartilage and be associated with...
3.
Gatasheh M, Murugan N, Krishnamoorthy R, Alshuniaber M, Malathi J, Umashankar V, et al.
Acta Trop
. 2024 Apr;
255:107216.
PMID: 38636584
According to the World Health Organization, infectious diseases, particularly those caused by multidrug-resistant bacteria (MDR), are projected to claim the lives of 15 million people by 2050. Septicemia carries a...
4.
Nagarajan H, Samdani A, Umashankar V, Jeyakanthan J
J Comput Aided Mol Des
. 2022 Jun;
36(6):459-482.
PMID: 35652973
LIMK2 inhibitors are one of the potential therapeutic modalities for treating various diseases. In the current scenario, there is a paucity of effective LIMK inhibitors that are highly specific with...
5.
Muthukumaran S, Sulochana K, Umashankar V
J Biomol Struct Dyn
. 2020 Jun;
39(14):5261-5275.
PMID: 32597331
Polyamine synthesis in human cells is initiated by catalytic action of Ornithine decarboxylase (ODC) on Ornithine. Elevated levels of polyamines are manifested proliferating cancer cells and are found to promote...
6.
Sadhasivam A, Nagarajan H, Umashankar V
J Biomol Struct Dyn
. 2019 Aug;
38(11):3131-3143.
PMID: 31380730
() is a major causative of infectious blindness in world. It is a real challenge to combat infection as it is an intracellular pathogen. Hence, it is essential to determine...
7.
John A, Sivashanmugam M, Natarajan S, Umashankar V
J Biomol Struct Dyn
. 2019 Jun;
38(7):1995-2006.
PMID: 31146646
Carbonic anhydrase IX (CAIX) is a tumour-associated, hypoxia-induced, membrane-bound metallo-enzyme which catalyzes the reversible hydration of carbon dioxide (CO) to bicarbonate (HCO) and proton (H) ions. Over expression of CAIX...
8.
Amit C, Muralikumar S, Janaki S, Lakshmipathy M, Lily Therese K, Umashankar V, et al.
Int J Nanomedicine
. 2019 Jan;
14:605-622.
PMID: 30697045
Background: Fungal keratitis is a major cause of corneal blindness accounting for more than one-third of microbiologically proven cases. The management of fungal keratitis is through topical or systemic antifungal...
9.
Rao B, Ansar S, Arokiasamy T, Sudhir R, Umashankar V, Rajagopal R, et al.
Ophthalmic Genet
. 2018 May;
39(4):443-449.
PMID: 29799290
Background: Fuchs' endothelial corneal dystrophy (FECD) is a complex degenerative disease of the corneal endothelium with genetic predisposition. Pathogenic rare variants have been identified in SLC4A11, LOXHD1, ZEB1, and AGBL1....
10.
Muthukumaran S, Bhuvanasundar R, Umashankar V, Sulochana K
Biomed Pharmacother
. 2017 Dec;
98:23-28.
PMID: 29241071
Ornithine Decarboxylase (ODC) is a key enzyme involved in polyamine synthesis and is reported to be up regulated in several cancers. However, the effect of ODC gene silencing in retinoblastoma...