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Vesa Oikonen

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Articles 104
Citations 2485
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Recent Articles
1.
Lehto J, Aarnio R, Tuisku J, Sucksdorff M, Koivumaki E, Nylund M, et al.
EJNMMI Res . 2024 Dec; 14(1):123. PMID: 39636350
Background: PET imaging of activated microglia has improved our understanding of the pathology behind disability progression in MS, and pro-inflammatory microglia at 'smoldering' lesion rims have been implicated as drivers...
2.
Bucci M, Rebelos E, Oikonen V, Rinne J, Nummenmaa L, Iozzo P, et al.
Metabolites . 2024 Feb; 14(2). PMID: 38393006
Accurate positron emission tomography (PET) data quantification relies on high-quality input plasma curves, but venous blood sampling may yield poor-quality data, jeopardizing modeling outcomes. In this study, we aimed to...
3.
Knuuti J, Tuisku J, Karpijoki H, Iida H, Maaniitty T, Latva-Rasku A, et al.
J Nucl Med . 2023 Nov; 64(Suppl 2):11S-19S. PMID: 37918848
Recently, PET systems with a long axial field of view have become the current state of the art. Total-body PET scanners enable unique possibilities for scientific research and clinical diagnostics,...
4.
Pekkarinen L, Kantonen T, Oikonen V, Haaparanta-Solin M, Aarnio R, Dickens A, et al.
Obesity (Silver Spring) . 2023 Jun; 31(7):1844-1858. PMID: 37368516
Objective: Cannabinoid type 1 receptors (CB1R) modulate feeding behavior and energy homeostasis, and the CB1R tone is dysgulated in obesity. This study aimed to investigate CB1R availability in peripheral tissue...
5.
Rainio O, Han C, Teuho J, Nesterov S, Oikonen V, Piirola S, et al.
J Digit Imaging . 2023 Apr; 36(4):1885-1893. PMID: 37106213
Carimas is a multi-purpose medical imaging data processing tool, which can be used to visualize, analyze, and model different medical images in research. Originally, it was developed only for positron...
6.
Savisto N, Gronroos T, Oikonen V, Rajander J, Loyttyniemi E, Bergman J, et al.
EJNMMI Res . 2023 Mar; 13(1):21. PMID: 36913049
Background: In the development of new F-labelled tracers, it is important to assess the amount of released [F]fluoride taken up in the bones of experimental animals because all F-labelled PET-tracers...
7.
Rebelos E, Mari A, Oikonen V, Iida H, Nuutila P, Ferrannini E
Metabolism . 2022 Dec; 141:155382. PMID: 36565992
Background/purpose: Studying renal glucose metabolism non-invasively in humans is an unmet need. Positron emission tomography (PET) is the current gold standard for measuring regional tissue glucose uptake rates, but the...
8.
Moisio O, Virta J, Yatkin E, Liljenback H, Palani S, Viitanen R, et al.
J Nucl Med . 2022 Oct; 64(4):555-560. PMID: 36302655
Bexmarilimab is a new humanized monoclonal antibody against common lymphatic endothelial and vascular endothelial receptor-1 (CLEVER-1) and is in clinical trials for macrophage-guided cancer immunotherapy. In addition being associated with...
9.
Sun L, Aarnio R, Atencio Herre E, Karna S, Palani S, Virtanen H, et al.
Eur J Nucl Med Mol Imaging . 2022 Sep; 50(2):266-274. PMID: 36166079
Purpose: Photoperiod determines the metabolic activity of brown adipose tissue (BAT) and affects the food intake and body mass of mammals. Sympathetic innervation of the BAT controls thermogenesis and facilitates...
10.
Brumberg J, Aarnio R, Forsberg A, Marjamaki P, Kerstens V, Moein M, et al.
J Cereb Blood Flow Metab . 2022 Sep; 43(2):258-268. PMID: 36163685
The membrane-based purinergic 7 receptor (P2XR) is expressed on activated microglia and the target of the radioligand [C]SMW139 for assessment of neuroinflammation. This study investigated the contribution of radiolabelled metabolites...