Venkatesh Chelvam
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Explore the profile of Venkatesh Chelvam including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
180
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Recent Articles
1.
Sengupta S, Pandit A, Krishnan M, Sharma R, Kularatne S, Chelvam V
Bioorg Chem
. 2025 Jan;
155():108130.
PMID: 39787914
Prostate cancer (PCa) has emerged to be the second leading cause of cancer-related deaths in men. Molecular imaging of PCa using targeted radiopharmaceuticals specifically to PCa cells promises accurate staging...
2.
Yadav K, Krishnan M, Chelvam V
Curr Protoc
. 2022 Dec;
2(12):e623.
PMID: 36571584
Local re-occurrence of cancer in patients with solid tumors is currently the most common reason for failure of treatment strategies. This fact indicates that prevailing approaches for tumor resection can...
3.
Krishnan M, Chelvam V
ACS Appl Bio Mater
. 2022 Jan;
4(5):4254-4270.
PMID: 35006838
Prostate-specific membrane antigen (PSMA) is a viable diagnostic biomarker for the detection and treatment of prostate cancer. Although numerous imaging techniques and fluorescent probes have been developed, targeted imaging and...
4.
Krishnan M, Yadav K, Chelvam V
Curr Protoc
. 2021 Jul;
1(7):e199.
PMID: 34288582
In recent years, 3D culture of tumor spheroids has managed to revolutionize cancer research and drug discovery. 2D monolayer cells grown in cell culture flasks undergo radical changes in cell...
5.
Dudhe P, Krishnan M, Yadav K, Roy D, Venkatasubbaiah K, Pathak B, et al.
Beilstein J Org Chem
. 2021 Jul;
17:1453-1463.
PMID: 34221174
1,5Disubstituted indole-2-carboxaldehyde derivatives - and glycine alkyl esters - are shown to undergo a novel cascade imination-heterocylization in the presence of the organic base DIPEA to provide 1-indolyl-3,5,8-substituted γ-carbolines -...
6.
Krishnan M, Pandit A, Sharma R, Chelvam V
J Biomol Struct Dyn
. 2021 Jun;
40(20):9909-9930.
PMID: 34180367
Early diagnosis of prostate cancer (PCa) is crucial for staging, treatment and management of patients. Prostate specific membrane antigen (PSMA), highly over-expressed on PCa cells, is an excellent target for...
7.
Krishnan M, Yadav K, Roach P, Chelvam V
Biomater Sci
. 2021 Feb;
9(6):2295-2312.
PMID: 33554988
The current challenge in fluorescence guided surgery (FGS) for prostate cancer (PCa) is in the design of imaging probes with high selectivity, clear visualization of tumour margins, and minimal toxicity....
8.
Sengupta S, Krishnan M, Chattopadhyay S, Chelvam V
Cancer Rep (Hoboken)
. 2020 Jul;
2(4):e1169.
PMID: 32721116
Background: Prostate-specific membrane antigen (PSMA), overexpressed on prostate cancer (PCa), is a well-characterized cell surface protein to selectively diagnose PCa. PSMA's unique characteristics and its 1000-fold higher expression in PCa...
9.
Dudhe P, Venkatasubbaiah K, Pathak B, Chelvam V
Org Biomol Chem
. 2020 Feb;
18(8):1582-1587.
PMID: 32048705
A serendipitous discovery of a novel one-pot synthesis of 4,6-disubstituted 5-azaindoles is reported herein. In the presence of Hunig's base, various N-substituted pyrrole-2-carboxaldehydes have been efficiently transformed into their corresponding...
10.
Sengupta S, Krishnan M, Pandit A, Dudhe P, Sharma R, Chelvam V
Bioorg Chem
. 2019 Aug;
91:103154.
PMID: 31404798
In this article, we have explored the chemical interactions of tyrosine-based asymmetric urea ligands in the binding pockets of prostate specific membrane antigen (PSMA) through in silico studies. The S1...